White matter tracts show increasing maturation with age from the back to the front of the brain. The maturations begin as a child reaches 9-12 years of age. The maturity correlates with a critical and formative period of development.
Fractional anisotropy values are reduced in the corpus callosum and middle orbital gyrus in obese teens. Researchers also discovered a positive correlation between these brain changes and neuroinflammation, insulin levels, and leptin resistance.