Fractional anisotropy values are reduced in the corpus callosum and middle orbital gyrus in obese teens. Researchers also discovered a positive correlation between these brain changes and neuroinflammation, insulin levels, and leptin resistance.
White matter tracts show increasing maturation with age from the back to the front of the brain. The maturations begin as a child reaches 9-12 years of age. The maturity correlates with a critical and formative period of development.
Methylphenidate, a drug given to help treat ADHD, affects specific tract in white matter in young boys. The effects are age dependant as the changes were not observed in adults who use the treatment. Researchers say the drug should only be given to children if they are significantly affected by ADHD in their daily lives.
An individual's level of general knowledge is associated with structural brain network connectivity. Fluid intelligence is best predicted by cortex volume in males, and by functional network connectivity in females.