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Down syndrome

·April 11, 2016·2 min read

Dysfunctional Endosomes Precede Hallmarks of Alzheimer’s Disease

Abnormalities are linked to axonal dysfunctions and neurodegeneration in Alzheimer's disease and Down syndrome, a new study reports.

Genetics

·February 2, 2012·4 min read

DNA Test that Identifies Down Syndrome in Pregnancy Can Also Detect Trisomy 18 and Trisomy 13

A newly available DNA-based prenatal blood test that can identify a pregnancy with Down syndrome can also identify two additional...

This image shows a microscopic view of neurons and amyloid plaques in the brain.

Featured Neurology

·October 23, 2014·4 min read

Why People with Down Syndrome Invariably Develop Alzheimer’s Disease

Study reveals how the SNX27 protein regulates the generation of beta amyloid.

Featured Neuroscience Psychology

·January 16, 2020·3 min read

Sleep linked to language skills in neurodevelopmental disorders

Sleep disruptions are common features of Fragile X syndrome, Williams syndrome, and Down syndrome. The disruption of sleep in these neurodevelopmental disorders appears to be linked to language development. The longer children with neurodevelopmental disorders slept, the more words they knew.

The image shows the location of the hippocampus in the human brain.

Featured Neurology

·July 2, 2013·4 min read

Drug Improves Cognitive Function in Mouse Model of Down Syndrome

Formoterol, an asthma medication, improves cognitive function in mouse models of Down syndrome.

Featured Neuroscience

·August 16, 2022·5 min read

Issues With Fracture Healing in People With Down Syndrome

Researchers report bone fractures in those with Down syndrome are unlikely to fully heal.

Featured Neuroscience Psychology

·October 29, 2018·5 min read

Daytime Naps May Hinder Learning in Children with Down Syndrome

A new study reports that while an afternoon naps are beneficial for memory and learning in typically developing children, in those with Down syndrome, napping may increase memory loss.

This image is a photo of a plastinated Alzheimer's brain.

Featured Genetics Neurology Open Neuroscience Articles

·July 21, 2015·4 min read

New Culprit in Alzheimer’s Disease Development Identified

Researchers have implicated a new culprit in the development of Alzheimer's disease. The findings could influence new strategies for treatment.

Featured Genetics Neurology

·October 11, 2018·4 min read

Human Brain Cell Transplant Offers Insight into Neurological Conditions

Researchers have successfully transplanted human brain cells into mouse brains and watched how they grow to form networks. The technique could be used to study a range of neurological conditions, the researchers report.

Featured Genetics Neuroscience

·May 23, 2019·3 min read

Targeting key gene could help lead to down syndrome treatment

Using stem cells from candidates with Down syndrome to create an organoid, and employing mouse models, researchers pinpoint a gene linked to memory impairments and cognitive problems in Down syndrome. Inhibiting the OLIG2 gene leads to cognitive and memory improvements in mouse models of Down. Researchers hope their findings lead to an in utero treatment that targets the gene and helps reverse abnormal brain development.