Using stem cells from candidates with Down syndrome to create an organoid, and employing mouse models, researchers pinpoint a gene linked to memory impairments and cognitive problems in Down syndrome. Inhibiting the OLIG2 gene leads to cognitive and memory improvements in mouse models of Down. Researchers hope their findings lead to an in utero treatment that targets the gene and helps reverse abnormal brain development.
Researchers have successfully transplanted human brain cells into mouse brains and watched how they grow to form networks. The technique could be used to study a range of neurological conditions, the researchers report.
A gene variant responsible for vascular damage to the brain is a promising new target for drug therapy to fight...
According to a new study, the cerebral cortex is thicker on average in those with Down syndrome, although the volume of the cortex is lower.
A new study sheds light into a possible cause of learning difficulties in Down syndrome.
In one of the first studies of its kind, UCLA researchers used a unique brain scan to assess the levels...
Researchers report extra copies of genes on chromosome 21 increase Alzheimer's like pathology and cognitive impairment in mouse models of Down syndrome. The findings provide insight into early onset Alzheimer's in those with Down syndrome.
Researchers discover a link between white matter health and the presence of dementia in adults with Down syndrome.