Study explains how an overexpression of the RCAN1 gene may cause intellectual disabilities in people with Down syndrome.
Using stem cells from candidates with Down syndrome to create an organoid, and employing mouse models, researchers pinpoint a gene linked to memory impairments and cognitive problems in Down syndrome. Inhibiting the OLIG2 gene leads to cognitive and memory improvements in mouse models of Down. Researchers hope their findings lead to an in utero treatment that targets the gene and helps reverse abnormal brain development.
A new study reports the dementia associated with Down syndrome involves defects in GSAP, which also malfunctions in Alzheimer's disease.
A newly available DNA-based prenatal blood test that can identify a pregnancy with Down syndrome can also identify two additional...
A new study sheds light into a possible cause of learning difficulties in Down syndrome.
Formoterol, an asthma medication, improves cognitive function in mouse models of Down syndrome.
Using induced pluripotent stem cells which were grown into brain cells, researchers were provided with a way to look at early brain development in Down syndrome.
Sleep disruptions are common features of Fragile X syndrome, Williams syndrome, and Down syndrome. The disruption of sleep in these neurodevelopmental disorders appears to be linked to language development. The longer children with neurodevelopmental disorders slept, the more words they knew.
Researchers have found that some second-trimester markers for Down’s syndrome detected by ultrasound increase the risk of giving birth to a child with the condition. The findings could help address the risks pregnant women face in having a child with Down’s syndrome.
A new study of gene activity in the brains of people with Down syndrome reveals the formation of white matter is affected throughout life.
Researchers have successfully transplanted human brain cells into mouse brains and watched how they grow to form networks. The technique could be used to study a range of neurological conditions, the researchers report.
According to a new study, over-expression of the Usp16 gene could be a major contributor to neurological deficits associated with Down syndrome.
