GM-CSF/sargramostim, a drug that improved memory in Alzheimer's patients during a phase II clinical trial, also appears to improve cognitive function in older adults and those with Down syndrome.
Sleep disruptions are common features of Fragile X syndrome, Williams syndrome, and Down syndrome. The disruption of sleep in these neurodevelopmental disorders appears to be linked to language development. The longer children with neurodevelopmental disorders slept, the more words they knew.
Using stem cells from candidates with Down syndrome to create an organoid, and employing mouse models, researchers pinpoint a gene linked to memory impairments and cognitive problems in Down syndrome. Inhibiting the OLIG2 gene leads to cognitive and memory improvements in mouse models of Down. Researchers hope their findings lead to an in utero treatment that targets the gene and helps reverse abnormal brain development.
A new study reports that while an afternoon naps are beneficial for memory and learning in typically developing children, in those with Down syndrome, napping may increase memory loss.
Researchers have successfully transplanted human brain cells into mouse brains and watched how they grow to form networks. The technique could be used to study a range of neurological conditions, the researchers report.
Researchers report extra copies of genes on chromosome 21 increase Alzheimer's like pathology and cognitive impairment in mouse models of Down syndrome. The findings provide insight into early onset Alzheimer's in those with Down syndrome.
Researchers track changes over decades and break down by racial groups the number of people diagnosed with Down syndrome.
Abnormalities are linked to axonal dysfunctions and neurodegeneration in Alzheimer's disease and Down syndrome, a new study reports.
Researchers have identified alterations in neural circuitry that impact cerebral cortex pathology. These alterations could be key to cognitive deficits in Down syndrome.