The VGLUT protein is more abundant in the dopamine neurons of female fruit flies, rodents, and humans than in males. The finding shed light on why females have greater resilience to age-related dopamine neuron loss and disorders such as Parkinson's disease.
PINK1, a gene associated with Parkinson's disease, is not just responsible for the premature death of dopaminergic neurons, it also plays a key role in the neurogenesis of dopamine neurons throughout life.
Dopamine neurons in the midbrain become active in a previously undetected way when an animal considers a reward that is changing in value.
Researchers administered PTB antisense oligonucleotide treatment directly to the midbrain of mice. In the mouse models exposed to the treatment, a small subset of astrocytes converted to neurons, increasing the number of neurons by 30%. Three months after treatment, mice were completely free of Parkinson's disease symptoms and remained in remission for the rest of their lives.
A new study reports neuromelanin sensitive MRI is able to measure dopamine function associated with psychosis.
Researchers shed light on the dual nature of dopamine, as a neurotransmitter that makes us seek pleasure and also reinforces avoidance of pain.
Researchers report dopamine neurons may play a role in fear extinction. The study suggests targeting dopamine neurons in the ventral tegmental area could be of therapeutic benefit to reduce the impact of learned fear in PTSD and anxiety disorders.
According to researchers, dopamine neurons may play a key role in the formation of episodic memory. The findings could help in the development of new treatments for neurodegenerative disorders that affect memory.
According to a new study to be published in eNeuro, amphetamine use may disrupt the development of the orbital prefrontal cortex, an area of the brain associated with decision making.
Yale researchers report the human brain contains some distinct patterns that mark our evolution and could contribute to our cognitive abilities.