Stem cell study reveals astrocytes carrying the Alzheimer's associated APOE4 gene release more cholesterol than those carrying the APOE3 gene. Findings shed light on how different versions of the APOE gene in astrocytes influence amyloid-beta production and how the oversupply of cholesterol associated with APOE4 astrocytes may promote amyloid-beta formation in Alzheimer's patients.
Study identifies the role a specific protein plays in regulating the development of inhibitory synapses in the hippocampus in the context of anxiety-related behaviors.
Regions of the olfactory system in mice with higher amyloid beta expression exhibited lower activation of olfactory sensory neurons and decreased odor detection.
Analyzing nasal discharge could be a new tool in diagnosing and monitoring the progression of Alzheimer's disease. Researchers found certain Alzheimer's related proteins can be detected in nasal discharge.
Chronic stress causes autophagy in adult hippocampal neural stem cells. This results in a decline of hippocampal neurogenesis. Cognitive deficits and mood disorders that arise as a result of chronic stress are a result of autophagic death of hippocampal neural stem cells.
According to a new study, liquiritigenin, a licorice extract, may help to inhibit dopaminergic neuronal cell death and could help slow the progression of Parkinson's disease.