Just as the familiar sugar in food can be bad for the teeth and waistline, another sugar has been implicated...
Researchers discover that an enzyme known for generating toxic brain plaques in Alzheimer's disease also causes additional memory and cognitive deficits via a separate mechanism. They found that BACE1 disrupts the cell's production of other molecules required for PKA function. By that mechanism, BACE1 inactivates PKA and therefore inhibits memory formation in mice, even in the absence of neurotoxic β-amyloid.
Buphenyl (sodium phenylbutyrate), a medication approved for the treatment of hyperammonemia, could help prevent the progression of Alzheimer's disease, a new study finds.
Researchers report estrogen may play a significant role in synaptic plasticity and memory formation. The study reports mice whose neurons did not produce estrogen have impairments in spatial reference memories, recognition and contextual fear memories. Restoring estrogen levels assisted in reversing the memory impairments, the study revealed.
Researchers have identified genes involved in long term memory in c.elegans.
The loss of fat metabolizing protein PPARalpha in the hippocampus can lead to dementia, a new study finds.
The expression of the CREB gene may function as a switch to regulate fear and extinction learning. The findings could provide a new avenue of treatment for PTSD and other mental health disorders.
A new study explores how neural activity influences CREB dynamics.
Researchers identify a molecular pathway which accelerates the time taken for antidepressants to work in mouse models.