CRISPR gene editing created the G795A amino acid which was introduced to microglia derived from human stem cells. Researchers were able to transplant the donor microglia immune cells into humanized rodent models while administering an FDA-approved cancer drug called pexidartinib. The inclusion of the amino acid cause the donated microglia to thrive and resist the drug, while the host microglia died. The findings open the door for new methods of using microglia to treat a range of neurodegenerative disorders.
Synaptic pruning occurs as a result of mechanical tearing, a new study reveals.
Researchers discovered a structure within the octopus nervous system by which the intramuscular nerve cords, which help the cephalopod to sense its arm movements, connect arms on the opposite side of the animal.
Optimal intake of B-type procyanidins, a class of polyphenols found in apples, cocoa, and red wine, is linked to metabolic and the hormesis of hemodynamic responses.
Using stimulation, researchers found a direct connection between the vagus nerve and learning centers of the brain. Vagus nerve stimulation, they discovered, increases learning in a healthy nervous system.
Magnetic microrobots move against fluid flow and precisely deliver substances to neural materials.
At the site of injury, nerves release a protein called CXCL12 which attracts growing nerve fibers and keeps them trapped in place. This prevents the nerve fibers from growing in the correct direction to bridge the injury site.
IgA cells that originate in the gut play a role appear to have neuroprotective properties against diseases associated with neuroinflammation, such as meningitis.
Researchers have devised techniques that allowed them to successfully replace dysfunctional microglia.