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City of Hope

·April 26, 2025·8 min read

Why Belly Fat Expands With Age, and How to Target It

New research uncovers that aging activates a new type of stem cell that rapidly produces fat cells, explaining why belly fat often expands in middle age. Scientists found that aging triggers adipocyte progenitor cells (APCs) to evolve into committed preadipocytes, age-specific (CP-As), which actively generate new fat.

This shows amyloid beta in a staining sample

Featured Neurology Neuroscience

·August 7, 2021·3 min read

Miniature Brain Models Developed to Study the Causes of Alzheimer’s and Test Drugs in Development

Researchers have developed a new brain organoid model to study the mechanistic causes of Alzheimer's disease and test dementia drugs currently in development.

This shows a man in a facemask surrounded by representations of covid-19

Featured Genetics Neurology Neuroscience

·February 4, 2021·4 min read

The Link Between ‘Alzheimer’s Gene’ and COVID-19

ApoE4, a gene associated with an increased risk of Alzheimer's disease, also appears to increase susceptibility and the severity of COVID-19. SARS-CoV-2, the virus responsible for coronavirus, increased susceptibility to COVID-19 in ApoE4 neurons and astrocytes in brain organoid models.

This shows the outline of a head and brain

Featured Neurology Neuroscience Open Neuroscience Articles

·May 14, 2019·4 min read

Probiotic-derived molecule may suppress fatal brain inflammation

Capsular polysaccharide A (PSA), an envelope molecule, may help to boost the immune system and protect against potentially fatal neuroinflammation associated with Herpes Simplex Encephalitis (HSE). Mice given PSA survived exposure to a lethal herpes simplex viral infection, while those not treated with the probiotic did not, despite both groups being treated with a common antiviral used to treat HSE.