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          chronic pain

          This shows a brain.
          FeaturedNeurologyNeurosciencePain
          ·October 8, 2025·8 min read

          Hunger, Fear, and the Brain’s Hidden Switch to Turn Off Chronic Pain

          Chronic pain affects nearly 50 million Americans, yet new research reveals the brain may have an internal switch that can turn it down. Scientists identified a group of neurons in the brainstem that regulate long-term pain by integrating signals related to hunger, fear, and thirst.
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          This shows a woman holding chocolate and a table with pain pills.
          FeaturedNeurologyNeurosciencePain
          ·October 8, 2025·6 min read

          Why Comfort Food Feels Like Medicine for People in Chronic Pain

          A new study reveals that more than two-thirds of people living with chronic pain turn to comfort foods—especially chocolate—for emotional relief and distraction during flare-ups. Eating provides temporary pleasure and even mild pain relief, likely due to biological effects of high-calorie foods on the brain’s reward and pain systems.
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          This shows a brain.
          FeaturedNeurologyNeurosciencePain
          ·June 20, 2025·4 min read

          Chronic Pain Linked to Neuron Overactivity in the Brainstem

          A new study reveals that neurons in the brainstem respond very differently to acute versus chronic pain, potentially explaining why some pain persists long after injury. In acute pain, neurons in the medullary dorsal horn reduce their activity through a natural “braking” system involving A-type potassium currents, helping limit pain signals.
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          This shows a neuron.
          FeaturedNeurologyNeurosciencePain
          ·December 9, 2024·3 min read

          New Target for Chronic Pain Identified

          Researchers have identified a natural substance, hederagenin, that blocks the NPFFR1 receptor, a protein involved in pain perception in the brain and spinal cord. NPFFR1 has long been a challenging target due to its similarities to related receptors, but advanced screening and computer modeling revealed its unique binding mode.
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          FeaturedGeneticsNeurosciencePain
          ·October 7, 2024·3 min read

          Genetic Mapping Unlocks Path to Effective Chronic Pain Relief

          Researchers have developed a comprehensive atlas that maps genetic activity in nerve cells linked to chronic pain, offering a potential breakthrough in non-addictive treatments. The study highlights key pain-sensitive nerve cell states, allowing for new therapeutic targets, such as senescent cells. Administering senolytic treatments in mice led to full recovery from pain without side effects, providing hope for chronic pain patients.
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          This shows pills and leaves.
          FeaturedNeurologyNeurosciencePain
          ·October 3, 2024·4 min read

          Chronic Pain Patients Favor Cannabis Legalization

          A study found that 71% of adults with chronic pain support federal legalization of medical cannabis, compared to 59% of physicians. The research highlights a gap in attitudes toward cannabis policies between patients and doctors, especially regarding insurance coverage for cannabis treatments.
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          This shows a neuron.
          FeaturedNeurologyNeurosciencePain
          ·August 20, 2024·3 min read

          Molecule Discovery Could Revolutionize Chronic Pain Treatment

          Researchers have identified a natural molecule, phosphatidic acid, that reduces the sensitivity of touch-sensing ion channels, providing a promising new avenue for managing chronic pain. By increasing levels of this molecule, cells become less sensitive to touch, which was confirmed through tests on sensory neurons and in mice. This discovery could lead to more targeted and effective treatments for conditions involving inflammatory pain.
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          This shows a person holding their head in pain.
          FeaturedNeurologyNeurosciencePain
          ·July 11, 2024·4 min read

          New Discovery Links Protein to Chronic Pain

          Researchers identified a new role for the PIEZO2 protein in mediating chronic pain hypersensitivity, suggesting a new target for pain relief. The study showed that mutations in PIEZO2 make pain receptors, or nociceptors, highly sensitive to mechanical stimuli, explaining persistent pain. This finding could lead to new analgesics that better address chronic pain by targeting PIEZO2 channels.
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          This shows a person rubbing their neck.
          FeaturedNeurologyNeurosciencePain
          ·April 22, 2024·5 min read

          Socioeconomic Factors Linked to Chronic Pain

          Socioeconomic status, lifestyle, and psychological factors significantly influence the development of chronic musculoskeletal pain after injury. The study found that individuals from lower socioeconomic backgrounds are twice as likely to experience chronic pain, and those with additional risk factors such as smoking, fear of movement, and poor support networks are up to seven times more likely.
          Read More
          This shows a man in pain
          FeaturedNeurologyPain
          ·April 22, 2023·5 min read

          Alcohol Fuels Pain: Study Reveals Link Between Drinking and Chronic Pain

          Chronic alcohol consumption can increase sensitivity to pain through two molecular mechanisms. Researchers also identified potential new drug targets for treating alcohol-related chronic pain. Over half of people with alcohol use disorder (AUD) suffer from persistent pain, including alcoholic neuropathy. The study found that alcohol withdrawal could result in neuropathy that was not reversed by re-exposure to alcohol.
          Read More
          This shows a drawing of a man holding his back in pain
          FeaturedNeurologyNeurosciencePain
          ·March 2, 2023·4 min read

          Study Investigates the Source of Back and Joint Pain With the Goal of Reverse Engineering Treatments

          Researchers investigate the degeneration process of musculoskeletal tissues that leads to chronic back and joint pain with the hope to translate their findings into new methods to repair tissue damage and ultimately relieve pain.
          Read More
          This shows a brain
          FeaturedNeurologyNeurosciencePain
          ·February 21, 2023·3 min read

          Study Finds Link Between Chronic Pain and Dementia

          People with chronic pain in multiple parts of the body have a higher risk of developing dementia and accelerated cognitive decline.
          Read More
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          Genetic Roots of Depression Reveal Strong Suicide Risk Signals

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          Why Sharing Good Deeds Feels Bad

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          No Evidence the Gut Microbiome Causes Autism

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          Why Women Face Worse Long COVID

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