Using gene editing to boost the production of SOD3 in the choroid plexus reduced oxidative damage to brain tissue and cerebral spinal fluid in mice exposed to methotrexate.
Researchers report people who are diabetic or who smoke are more likely to have calcification in the hippocampus. The study hypothesized hippocampal calcification may contribute to cognitive deterioration and brain atrophy.
Using mouse models, researchers have developed a comprehensive map of the brain's immune cells. The study found microglia in the choroid plexus showed a similar activation state as microglia that come into contact with Amyloid deposits.
The vascular barrier in the choroid plexus locks down access to the brain in response to gut inflammation that causes IBD. The dysregulated activity of the gut-brain vascular axis appears to protect the brain from inflammation. However, the mechanism may increase the risk of both cognitive and mental health problems associated with IBD.
Researchers believe their findings could eventually help produce treatments to slow or reverse cognitive decline in older people.
Immaturity of the gut microbiome and epithelial barriers in the gut and choroid plexus appear to play a significant role in neonatal susceptibility to meningitis.
Activating group 2 innate lymphoid cells in aging brains helps improve memory in mice. The findings could help in the development of treatments for neurodegenerative diseases associated with aging.
A new study reports that increased volume in the choroid plexus appears to be associated with greater cognitive impairment and Alzheimer's disease.
Mouse study reveals the choroid plexus can act as a conduit for inflammation that can arise from maternal inflammation, impacting fetal brain development.