Dopamine D2 receptor overexpression in cholinergic interneurons of the nucleus accumbens may explain why some are more prone to cocaine addiction than others.
Male alcohol consumption before conception was linked to significant deficits in their offspring's brain development, specifically within the neocortex. For mothers-to-be who drink alcohol, the negative outcomes of prenatal alcohol exposure on fetal brain development can be reduced with choline supplementation.
Findings show sex-specific baizes in gene expression changes and demonstrate cellular control mechanisms based on microRNA change. The study sheds new light on genetic and neurological changes associated with schizophrenia and bipolar disorder.
Taking dietary choline supplements may help to protect the brain from Alzheimer's disease. Choline reduces the activation of microglia which, when overactivated, contribute to neuroinflammation and apoptosis associated with Alzheimer's. Choline also helps block the production of amyloid plaques.
POMC, a gene which regulates the stress response system, and PER2, a gene associated with circadian regulation, are altered in women who drank moderate-to-high amounts of alcohol during pregnancy and their newborns.
Adding extra choline through eggs or meat to your daily diet could help stave off the effects of dementia. Higher phosphatidylcholine intake through diet was associated with lower rates of dementia and improved cognitive function in aging men.
Maternal cannabis negatively impacts fetal brain development at an early stage of pregnancy than was previously believed. However, increasing choline consumption, either through diet or supplementation, could help protect the developing brain from potential harm.
Preterm babies who were fed breastmilk had significantly higher levels of creatine and choline, key metabolites for brain growth and development, than those who were formula fed.
Choline, an essential nutrient, can help prevent fetal brain development problems in infants whose mothers experience common infections, such as influenza, during pregnancy.