CBD reduces craving and anxiety in those with heroin use disorder during withdrawal from the drug. There were no serious adverse reactions, or impairments to cognition noted with the administration of CBD. Researchers suggest cannabidiol may be useful in helping to combat opioid addiction.
A two-week course of CBD helps normalize and restore the function of two proteins associated with reducing amyloid-beta accumulation in mouse models of familial Alzheimer's disease. CBD also reduces levels of IL-6, an immune protein associated with inflammation in Alzheimer's patients.
Cannabidiol (CBD) appears to slow the growth of glioblastoma brain cancer cells in both animal and human cell lines. CBD's anti-cancer actions target mitochondria, causing them to dysfunction and release harmful reactive oxygen species. Cancer cells treated with CBD exhibited significant decreases in mitochondrial activity.
A new study in Zebrafish reveals exposure to compounds found in cannabis during the early stages of development was linked to a significant drop in neural activity later in life.
Many cannabis users don't know how much THC or CBD is considered an effective dose.
Marijuana use alters a gene associated with autism in sperm. Hypomethylation was identified in the DLGAP2 gene in the sperm of male rats exposed to THC. The hypomethylated state was also detected in the forebrains of their offspring. Further research is needed to establish if there is a definitive link between paternal cannabis use and ASD in humans.
Eating a high-fat diet can help with the absorption of oral CBD for those with epilepsy. Previous studies have linked CBD to helping manage seizures associated with epilepsy.
During memory tasks, people with psychosis have different patterns of activity in the prefrontal and mediotemporal brain areas compared to those without the disorder. When exposed to cannabidiol (CBD), the activity of the brain areas became more like those seen in the controls for people with psychosis. Patients reported a decrease in symptoms of psychosis following one dose of CBD. Researchers stress that no definitive conclusions could be made about the effectiveness of CBD use over a sustained period.
Staphylococcal enterotoxin, a bacterial toxin implicated in some ARDS cases, can be prevented by treatment with the cannabis compound THC. Findings also suggest a potential role for using cannabinoids to treat ARDS caused by COVID-19.