c-Fos accumulates in the nucleus of peripheral nerve cells of mouse models of chronic pain. Researchers identified around 30 existing drugs that appear to target the importin alpha-3-c-Fos pathway to help treat chronic pain.
Activity of the c-Fos gene begins the increase on the ninth day of exposure to antidepressants. By day 14, mice showed behavioral changes associated with SSRI use. This may explain why suicide rates drop after nine days of treatment, and symptoms of depression improve after three weeks.
Axolotl salamander genes that allow the neural tube and nerve fibers to regenerate after spinal cord damage have been identified. These genes are also found in humans, but are activated differently.
Researchers report the gamma-CaMPII protein plays a critical role in learning and memory. The shuttle protein may be dysfunctional in those with Schizophrenia and autism, hindering learning abilities, researchers report.
Researchers have discovered two small brain regions in mice that control whether the animal will commit infanticide or will take on an attentive paternal role.