DIPG cancer cells exposed to MI-2 fail to maintain healthy levels of cholesterol and die quickly, by inhibiting lanosterol synthase. Additionally, while MI-2 destroys glioma cancer cells, the drug does not damage healthy brain cells.
Researchers discovered changes in thousands of genes induced by the tumor microenvironment. The study may help in identifying new biomarkers for the early detection, and subsequent treatment, of brain cancers.
PTEN deficiency drives an increased expression of LOX. LOX attracts macrophages which protect gliobastoma brain cancer cells and provide growth factor support for the tumor, a new mouse study reveals.
After a single session of transcranial electrical stimulation (tES), researchers noted a significant reduction in blood flow to brain tumors. However, there were no alterations in blood flow or activity in the rest of the brain. The technique may be helpful in the treatment of brain cancers such as glioblastoma.
A new artificial intelligence convolutional neural network is 94.6% accurate at diagnosing real-time intraoperative brain tumors.
Glioma brain tumors alter the function of astrocytes, possibly contributing to seizures many brain cancer patients experience. Astrocytes encasing gliomas exhibit different molecular signatures based on their proximity to the cancer cells. Those directly touching the cancer cells become elongated and swollen, mimicking the astrocyte's response to other epilepsy-related brain injuries.
Researchers have identified specific characteristics of vestibular schwannomas in children. While children have similar symptoms of the brain tumors as experienced by adults, the tumor size was typically larger in pediatric patients at the time of diagnosis.