The epigenetic histone mutation H3.1K27M works in combination with ACVR1 mutations to cause diffuse intrinsic pontine glioma tumors to form and grow quickly.
Researchers discovered changes in thousands of genes induced by the tumor microenvironment. The study may help in identifying new biomarkers for the early detection, and subsequent treatment, of brain cancers.
DIPG cancer cells exposed to MI-2 fail to maintain healthy levels of cholesterol and die quickly, by inhibiting lanosterol synthase. Additionally, while MI-2 destroys glioma cancer cells, the drug does not damage healthy brain cells.
A new vaccine for glioblastoma brain cancer suspends tumor growth and is well tolerated by patients, according to the results of an early phase clinical trial.
Combining carboplatin, a common chemotherapy drug, with everolimus, a drug that blocks mTOR, is effective at inducing apoptosis and slowing tumor growth in patients with pediatric low-grade glioma brain cancer.
Researchers have developed a new approach that uses microRNA in combination with chemotherapy to help treat glioblastoma brain cancer. In preclinical models, the approach increases survival of the deadly brain cancer five fold.
Researchers report our gender can determine longevity and response to treatment for glioblastoma brain cancer. The study reports male survival is determined by genes that control cell division, where as female survival is often determine by genes that regulate the ability of cancer cells to migrate to different brain areas.
A new study reveals how the physical force exerted by the solid components of brain tumors impacts surrounding tissue, resulting in apoptosis and neurological dysfunction. Researchers reports the drug lithium, commonly prescribed for bipolar disorder, can help reverse some of the damage caused by the solid stress of the tumor.
A new study reports bigger brain size could mean an increased risk of developing brain cancer. The reason, researchers say, is simple. Bigger brains have more brain cells, and thus a greater potential for cell mutations that lead to cancer.
Using an open source platform called The Virtual Brain, researchers have simulated neural activity based on individual patient brain tumors.
A newly developed model that mimics the blood-brain barrier could help researchers more efficiently test drugs to treat a range of neurological diseases.
Researchers discover key elements associated with tumor cells binding to blood vessels. The findings could help develop new treatments to halt the development of brain tumors.
