After inserting a gene into mice that increases choline transporter and as a result increases acetylcholine at the neuromuscular junctions, the engineered mice were able to run on treadmills twice as long as controls without the inserted gene.
The removal of a certain class of potassium channels from the surface of nociceptors is believed to be a key factor in inflammatory pain signaling. Using gene interference to reduce the expression of these specific potassium channels on nociceptors, researchers were able to produce hyperexcitability in nociceptors resembling that seen in inflammatory pain signaling.
A woman with bilateral damage relatively restricted to the amygdala is the subject of a case study reported today. SM, as she will be known to the public, seems able to experience emotions such as happiness and sadness normally, but shows no signs of fear.
Fragile X Tremor Ataxia Syndrome (FXTAS) research shows that inhibiting histone acetylation could help control expression of toxic mRNA. FXTAS symptoms are mainly caused by overproduction of toxic mRNA, making this research very important for researchers working with FXTAS.
The world's first basic research institute for childhood neurological diseases opened in Houston, Texas and is part of the Texas Children's Hospital. Some of the research the new research insitute will focus on includes childhood neurological diseases such as autism, epilepsy, Rett syndrome, cerebral palsy, ataxias and Batten disease. More details about the new institute are provided in the press release below.
The removal of beta-amyloid is not efficient in late-onset Alzheimer's disease sufferers. These new findings could help produce better early diagnostic tests and therapies for Alzheimer's disease and related research.
New research on learning describes the interaction between acetlycholine receptors and SK channels and their involvement in learning and memory. These findings could lead to new research targeting acetylcholine and SK channels to help cognitive disorders such as Alzheimer's disease and schizophrenia as well as help understand learning and memory better.
Zif proteins have been found to control whether a brain stem cell differentiates into a neuron or renews as a brain stem cell. There are Zif related proteins in humans that may be targeted by new treatments for brain cancer and other diseases.
Computational neuroscience research provides new information on the N-type calcium channel and synaptic transmission. The computational neuroscience model investigated shows that a single open N-type calcium channel's current may be sufficient to enable neurotransmitter release.