A mutation in a gene associated with circadian rhythm extends the clock period, causing people to stay up late at night and sleep late in the mornings.
Deleting the circadian rhythm-associated BMAL1 gene in animal models, researchers discovered tissue continued to follow a 24-hour rhythm, even in the absence of external stimuli that can influence the cycle.
Removing BMAL1, a gene commonly associated with circadian rhythm, makes macrophages more effective and the body more resistant to pneumonia.
Skin and liver cells appear to have their own circadian clock. Both the liver and skin respond to changes in light and maintain critical function, independent of the brain's circadian rhythm.
Researchers in China successfully used CRISPR gene editing to produce five monkey clones from the fibroblasts of a donor monkey with disease phenotypes.
Researchers report fasting affects the circadian rhythm of the liver and skeletal muscles, allowing them to rewire their metabolism. The study suggests fasting can help improve health and protect against aging related diseases.
A new study sheds light on how the circadian clock controls inflammatory response. By understanding the link between inflammation and circadian rhythm, researchers believe it may be most effective to target specific conditions at certain times of the day. The findings may also explain why those who experience body clock disruptions are more susceptible to inflammatory conditions.
A new study reports misfolded proteins can cause circadian rhythm disruptions which contribute to cancerous tumor growth.
Researchers shed light on how the circadian rhythm and time of day impact immune response in autoimmune diseases. The findings could help in the development of new treatments to tackle a range of autoimmune disorders.
According to researchers, increasing levels of Bmal1 in the skeletal muscles of mice makes the animals resistant to insomnia and sleep deprivation. The findings could provide a new treatment target for sleep disorders.
A new study reveals mice with higher levels of BMAL1 in their muscles were able to recover from sleep deprivation more quickly than those with the protein removed.
A new study reports that disrupting the natural circadian rhythm in mice causes depression and anxiety.
