Deleting the circadian rhythm-associated BMAL1 gene in animal models, researchers discovered tissue continued to follow a 24-hour rhythm, even in the absence of external stimuli that can influence the cycle.
Skin and liver cells appear to have their own circadian clock. Both the liver and skin respond to changes in light and maintain critical function, independent of the brain's circadian rhythm.
Researchers discover the expression of certain clock genes plays a critical role in delaying the emergence of age-related signs in the brain.
According to researchers, a cancer causing gene may affect the circadian clock and metabolism by binding to promoter regions in genes responsible for maintaining these biological functions.
A new study reports misfolded proteins can cause circadian rhythm disruptions which contribute to cancerous tumor growth.
According to researchers, changes in the abundance of gut bacteria in female mice is tied to the rhythms of the internal clock.
A new study reports that disrupting the natural circadian rhythm in mice causes depression and anxiety.
Researchers in China successfully used CRISPR gene editing to produce five monkey clones from the fibroblasts of a donor monkey with disease phenotypes.
A mutation in a gene associated with circadian rhythm extends the clock period, causing people to stay up late at night and sleep late in the mornings.
Researchers report fasting affects the circadian rhythm of the liver and skeletal muscles, allowing them to rewire their metabolism. The study suggests fasting can help improve health and protect against aging related diseases.
A new study sheds light on how the circadian clock controls inflammatory response. By understanding the link between inflammation and circadian rhythm, researchers believe it may be most effective to target specific conditions at certain times of the day. The findings may also explain why those who experience body clock disruptions are more susceptible to inflammatory conditions.
Researchers have discovered an important mechanism which allows animals to effectively track seasonal changes.
