The largest genetic map of mental health disorders to date reveals there are three groups of highly genetically related disorders among eight psychiatric disorders. A gene related to nervous system development is a risk factor for all eight disorders studied. The RBFOX1 gene is implicated in seven of the eight disorders. ADHD and depression share 44% of genetic risk factors common in the general population. 109 pleiotropic loci affect more than one disorder. These pleiotropic loci are within genes that show heightened expression in the brain through the lifespan, beginning during the second trimester of pregnancy.
Researchers report mitochondrial dysfunction may affect the activity of serotonergic neurons in mice with ANT1 mutations. The findings may provide insight into the origins of bipolar disorder.
According to a new study, adolescents with bipolar disorder show differences in brain development in areas that help regulate emotion.
Researchers report bipolar depression and schizophrenia may be detectable several years before symptoms appear. A new study reports 50% of patients diagnosed with schizophrenia or bipolar disorder attended specialist child and adolescent mental health services during childhood.
Study reveals patients with bipolar disorder have a significantly increased risk of developing Parkinson's disease compared with the general population.
Computer analysis of patients reveals five clearly defined subgroups of psychosis and bipolar disorder. Those in group two were more likely to exhibit suicidal tendencies, while those in group five, for example, were characterized by schizophrenia diagnosis and lower verbal intelligence scores. Defining the characteristics of the subtypes could lead to improved personalized treatments for psychosis related mental illnesses.
Researchers discover common white matter abnormalities in multiple emotional disorders.
A new study reports different subtypes of bipolar disorder tend to cluster within families, suggesting that even though there are genetic similarities that indicate overlap between subtypes, each has a different origin.
Research has long revealed an association between belief in conspiracy theories and mental health disorders. A new study reports followers of the radical QAnon group are significantly more likely to suffer from mental health problems, including depression, anxiety, and schizophrenia, than the general population.
People with bipolar disorder who experience frequent manic episodes had faster cortical thinning, specifically in the prefrontal cortex than those who reported less frequent episodes of mania. Researchers also noted faster enlargement of the brain's ventricles and slower thinking of the parahippocampal and fusiform cortical regions in those who experienced more frequent mania.