While patients with schizophrenia, major depressive disorder, and bipolar disorder experience a lack of motivation and anhedonia, the neural patterns of emotion-behavior dissociation differ between the disorders.
Analyzing previous studies, researchers have identified the effects of individual and environmental risk factors for suicide over a person's lifespan. The risk factors, researchers report, change throughout a person's lifetime.
Researchers report the CPG2 protein is significantly decreased in the brains of people with bipolar disorder and mutations in the SYNE1 gene undermines the expression of CPG2. The study shows how a set of genetic differences in those with bipolar disorder can lead to specific psychological dysfunction in synapses in the brain. The findings could help improve diagnosis of the disorder and help develop new treatments for BD.
Researchers report common symptoms of bipolar depression and schizophrenia, such as depression, psychosis and mania, have shared and distinguished genetic risk factors. The findings could help with the development of more effective therapies for these neuropsychological disorders.