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BBB

This shows the outline of a body and a red brain

·February 6, 2021·5 min read

Critical Flaw Found in Lab Models of the Human Blood-Brain Barrier

Human brain endothelial cells used to generate lab models of the human blood-brain barrier were missing several key proteins found in natural endothelial cells. The cells had more in common with epithelial, a type of cell not normally found in the brain. The findings put into question over a decade worth of lab-based research on the BBB.

Featured Neurology Neuroscience

·January 1, 2021·5 min read

Nanoparticle Drug-Delivery System Developed to Treat Brain Disorders

A new nanoparticle drug-delivery system resulted in unprecedented siRNA penetration across the intact blood-brain barrier. Researchers say the system could help doctors to treat secondary injuries associated with TBI that can result in Alzheimer's and other neurodegenerative disorders.

Featured Neuroscience

·September 21, 2020·5 min read

Advancing Understanding of Blood-Brain Barrier Health

Study reveals the important role astrocytes play in maintaining blood-brain barrier health.

This shows the drug transportation over the bbb via neurotransmitters

Featured Neuroscience Open Neuroscience Articles

·July 24, 2020·5 min read

Novel Drug Delivery Particles Use Neurotransmitters as a ‘Passport’ Into the Brain

Tufts researchers have developed neurotransmitter-lipid hybrids that help transport therapeutic drugs and gene editing proteins across the blood-brain barrier in mice.

Featured Genetics Neurology Neuroscience

·April 29, 2020·4 min read

APOE4 triggers early breakdowns in the blood-brain barrier

APOE4, a gene implicated as a risk factor for Alzheimer's disease, triggers leaks in the blood-brain barrier. The damage to capillaries APOE4 causes correlates with increased levels of cyclophilin, a protein that causes the inflammation that is a signature of early Alzheimer's.

Featured Neuroscience

·April 17, 2020·3 min read

New nanocarrier drug delivery technology crosses the blood-brain barrier

Researchers have developed a cyclic peptide that can enhance blood-brain barrier penetration.

Featured Genetics Neuroscience Open Neuroscience Articles

·February 28, 2020·3 min read

Our own immune cells damage the integrity of the blood-brain barrier

Microglia initially protects the blood-brain barrier from damage due to systemic inflammation. However, microglia can alter their behavior and increase the permeability of the blood-brain barrier, thus damaging it.

Featured Neurology Neuroscience

·December 29, 2019·7 min read

Drugs that quell brain inflammation reverse dementia

Older mice given anti-inflammatory medication were better able to learn new tasks and became almost as adept at learning as mice half their age.

Featured Neurology Neuroscience

·December 4, 2019·6 min read

Drugs that quell brain inflammation reverse dementia

A synthesized small-molecule drug blocks the TGF-beta receptor in astrocytes and traverses the blood-brain barrier in mice. When administered, the drug lowered receptor activity to that seen in younger mice and reduced inflammation. The aged mice were able to navigate mazes and learn spatial tasks as well as younger mice.

Featured Neurology Neuroscience

·June 6, 2019·5 min read

Ultrasound method restores dopaminergic pathway in brain at Parkinson’s early stages

Using transcranial focused ultrasound in combination with injectable microbubbles, researchers open a pathway through the blood-brain barrier. The technique allows drugs to penetrate the brain and trigger therapeutic effects for those with neurodegenerative diseases.

This shows the BBB created on the organ-chip

Featured Neurology Neuroscience

·June 6, 2019·4 min read

Scientists recreate blood-brain barrier defect outside the body

Using induced pluripotent stem cells derived from patients with neurodegenerative disorders, researcher recreated the blood-brain barrier inside Organ-Chips.