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autophagy

This image is a brain slice showing glycogen accumulation in the brain.

·February 28, 2014·4 min read

Researchers Reveal the Dual Role of Brain Glycogen

Researchers report an accumulation of glycogen in Lafora disease directly causes apoptosis, triggers autophagy and synaptic failure.

Featured Neurology

·December 13, 2017·3 min read

Cellular Self Digestion Process Triggers Autoimmune Disease

A new study reveals how autophagy in certain immune cells can lead to the immune system attacking the central nervous system. The findings have implications for the treatment of autoimmune diseases, like multiple sclerosis.

Featured Neurology Open Neuroscience Articles

·December 1, 2016·4 min read

Key Cause of Parkinson’s Can Be Treated

Researchers have identified a potential mechanism to help control inflammation associated with Parkinson's disease.

This image is a neuron from the brain of a young person with autism.

Autism Electrophysiology Featured

·August 21, 2014·5 min read

Children with Autism Have Extra Synapses in Brain

According to a new study, children with autism have an excess of synapses in the brain, due to a slowdown of the normal pruning process during development.

Featured Neuroscience Open Neuroscience Articles

·November 2, 2017·3 min read

Synaptic Disorder

Targeting autophagy may help in the battle against ALS and other diseases that affect motor neurons, researchers report.

This image shows the stem cell derived motor neurons from an ALS patient.

Featured Genetics Neurology

·February 19, 2015·6 min read

New ALS Gene and Signaling Pathways Identified

Researchers have identified a new gene associated with ALS.

The image shows role of autophagy in Aβ secretion from neurons.

Featured Neurology Open Neuroscience Articles

·October 3, 2013·2 min read

Cell Auto Cleaning Mechanism Mediates the Formation of Plaques in Alzheimer’s

Using transgenic mice, researchers find a lack of autophagy in neurons prevents the secretion of amyloid beta and the formation of β-amyloid plaques in the brain.

Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·April 10, 2019·4 min read

Protein pileup affects social behaviors through altered brain signaling

Study implicates disrupted autophagy and protein aggregation in the pathogenesis of autism schizophrenia and social behavior deficits in other disorders.

Featured Neurology Neuroscience Open Neuroscience Articles

·April 18, 2019·4 min read

Blood pressure drug shows promise for treating Parkinson’s and dementia in animal study

Felodipine, a common hypertension medication, induces autophagy and clears aggregate-prone proteins associated with neurodegenerative diseases. The study reveals the drug clears mutant alpha-synuclein in the brains of mice at plasma concentrations to those seen in humans taking the medication. Felodipine appears to have some neuroprotective properties in mouse models of neurodegenerative diseases.

This shows the outline of a woman and a brain

Featured Neuroscience Open Neuroscience Articles

·March 11, 2022·2 min read

Brain Stress Factor Regulates Obesity

FKBP51, a protein linked to depression and anxiety disorders, also acts as a link between the stress response system and metabolic processes.

Featured Genetics Neuroscience

·September 16, 2017·7 min read

Unveiling the Mystery of Why We Age

Researchers have identified genes that contribute to autophagy. The findings shed light on the origins of the aging process and provide evidence that aging arises as a quirk of evolution.