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autophagy

·June 13, 2026·9 min read

Autophagy Decline in Older Moms Halts Embryo Development

A new study demonstrates that a decline in autophagy within embryos from advanced maternal age drives an abnormal over-activation of lipid metabolism that causes developmental arrest.

Featured Neurology Neuroscience

·May 28, 2026·9 min read

Neuronal AcCoA Signaling Linked to Autophagy Defects in Alzheimer’s

Neurons and glial cells utilize a specialized metabolic mechanism centered on leucine-derived acetyl-coenzyme A (AcCoA) to regulate the master growth hub, mTORC1.

Featured Neuroscience

·February 18, 2026·8 min read

Sleep Protects the Brain’s Powerhouses from Toxic Waste

Think of sleep as a janitorial shift. New research reveals how slumber protects your brain’s powerhouses by hauling away toxic waste produced during the day.

Featured Neuroscience

·December 2, 2024·6 min read

Ketone Bodies Clear Damaged Proteins in the Brain

Ketone bodies, known for their role in energy metabolism during fasting, have been shown to directly interact with damaged proteins in the brain, aiding their clearance through autophagy. Researchers discovered that the ketone body β-hydroxybutyrate alters the solubility of misfolded proteins, facilitating their removal and reducing pathological aggregation.

Featured Neurology Neuroscience

·October 28, 2022·6 min read

Cellular Housekeeping Process Implicated in Huntington’s Disease

Study reveals how aging impairs autophagy and how enhancing autophagy can prevent cells from dying in Huntington's disease.

Featured Genetics Neuroscience Open Neuroscience Articles

·June 5, 2022·3 min read

Studying Autophagy to Help Us Understand the Mechanisms of Aging-Related Diseases

Researchers have identified the cellular and molecular mechanisms that regulate selective autophagy.

Featured Neurology Neuroscience

·June 2, 2022·5 min read

Evidence Mounts for Alternate Origins of Alzheimer’s Disease Plaques

A new mouse study reveals a breakdown in the process that clears brain cells of waste products precedes the buildup of amyloid plaques associated with Alzheimer's disease.

This shows the outline of a woman and a brain

Featured Neuroscience Open Neuroscience Articles

·March 11, 2022·2 min read

Brain Stress Factor Regulates Obesity

FKBP51, a protein linked to depression and anxiety disorders, also acts as a link between the stress response system and metabolic processes.

Featured Neurology Neuroscience

·July 15, 2021·4 min read

Autophagy May Be the Key to Finding Treatments for Early Huntington’s Disease

Disruption of autophagy may be at the root of the cognitive deficits experienced by those with Huntington's disease.

Brain Cancer Featured Neurology Neuroscience

·December 23, 2020·4 min read

Anti-Diarrhea Drug Drives Cancer Cells to Cell Death

Loperamide, an anti-diarrhea medication, induces autophagy in glioblastoma brain cancer cells.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles Psychology

·August 9, 2019·3 min read

How chronic stress causes brain damage

Chronic stress causes autophagy in adult hippocampal neural stem cells. This results in a decline of hippocampal neurogenesis. Cognitive deficits and mood disorders that arise as a result of chronic stress are a result of autophagic death of hippocampal neural stem cells.

Featured Genetics Neuroscience Open Neuroscience Articles

·July 19, 2019·3 min read

Taking out the Protein Garbage Becomes More Difficult as Neurons Age

In aging mice, the number of autophagosomes is significantly decreased, and pronounced defects in the structure of autophagosomes increased. Turning on the WIPI2B protein restores autophagosome formation in aged neurons.