FeaturedNeuroscience·December 2, 2024·6 min readKetone Bodies Clear Damaged Proteins in the BrainKetone bodies, known for their role in energy metabolism during fasting, have been shown to directly interact with damaged proteins in the brain, aiding their clearance through autophagy. Researchers discovered that the ketone body β-hydroxybutyrate alters the solubility of misfolded proteins, facilitating their removal and reducing pathological aggregation.Read More
FeaturedNeurologyNeuroscience·October 28, 2022·6 min readCellular Housekeeping Process Implicated in Huntington’s DiseaseStudy reveals how aging impairs autophagy and how enhancing autophagy can prevent cells from dying in Huntington's disease.Read More
FeaturedGeneticsNeuroscienceOpen Neuroscience Articles·June 5, 2022·3 min readStudying Autophagy to Help Us Understand the Mechanisms of Aging-Related DiseasesResearchers have identified the cellular and molecular mechanisms that regulate selective autophagy.Read More
FeaturedNeurologyNeuroscience·June 2, 2022·5 min readEvidence Mounts for Alternate Origins of Alzheimer’s Disease PlaquesA new mouse study reveals a breakdown in the process that clears brain cells of waste products precedes the buildup of amyloid plaques associated with Alzheimer's disease.Read More
FeaturedNeuroscienceOpen Neuroscience Articles·March 11, 2022·2 min readBrain Stress Factor Regulates ObesityFKBP51, a protein linked to depression and anxiety disorders, also acts as a link between the stress response system and metabolic processes.Read More
FeaturedNeurologyNeuroscience·July 15, 2021·4 min readAutophagy May Be the Key to Finding Treatments for Early Huntington’s DiseaseDisruption of autophagy may be at the root of the cognitive deficits experienced by those with Huntington's disease.Read More
Brain CancerFeaturedNeurologyNeuroscience·December 23, 2020·4 min readAnti-Diarrhea Drug Drives Cancer Cells to Cell DeathLoperamide, an anti-diarrhea medication, induces autophagy in glioblastoma brain cancer cells.Read More
FeaturedGeneticsNeurologyNeuroscienceOpen Neuroscience ArticlesPsychology·August 9, 2019·3 min readHow chronic stress causes brain damageChronic stress causes autophagy in adult hippocampal neural stem cells. This results in a decline of hippocampal neurogenesis. Cognitive deficits and mood disorders that arise as a result of chronic stress are a result of autophagic death of hippocampal neural stem cells.Read More
FeaturedGeneticsNeuroscienceOpen Neuroscience Articles·July 19, 2019·3 min readTaking out the Protein Garbage Becomes More Difficult as Neurons AgeIn aging mice, the number of autophagosomes is significantly decreased, and pronounced defects in the structure of autophagosomes increased. Turning on the WIPI2B protein restores autophagosome formation in aged neurons.Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·April 18, 2019·4 min readBlood pressure drug shows promise for treating Parkinson’s and dementia in animal studyFelodipine, a common hypertension medication, induces autophagy and clears aggregate-prone proteins associated with neurodegenerative diseases. The study reveals the drug clears mutant alpha-synuclein in the brains of mice at plasma concentrations to those seen in humans taking the medication. Felodipine appears to have some neuroprotective properties in mouse models of neurodegenerative diseases.Read More
FeaturedGeneticsNeuroscienceOpen Neuroscience ArticlesPsychology·April 10, 2019·4 min readProtein pileup affects social behaviors through altered brain signalingStudy implicates disrupted autophagy and protein aggregation in the pathogenesis of autism schizophrenia and social behavior deficits in other disorders.Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·January 2, 2019·2 min readHyperactive Immune System Implicated in Aging Brain DisordersAccording to a new study, the immune system may play a critical role in damage associated with neurodegenerative disorders such as Alzheimer's disease and ALS. The study reports altering Cdk5 results in the death of dopamine neurons and slowed autophagy.Read More
