Researchers identify regions of genes linked to Behçet’s disease, a poorly understood condition that causes painful and serious symptoms, including ulcers and brain inflammation. The study identified novel gene variants in the inflammatory disorder and uncovered data that could apply to studies of other diseases.
New findings could help point the way to new targets for developing treatments for multiple sclerosis.
Researchers report disruption of the BBB can trigger a cascade of events that result in brain damage and autoimmunity characteristic of MS.
Using CRISPR gene editing, researchers mapped important genes for helping T helper cells. The findings could help generate new treatments to activate the immune system against infection and to attack tumor cells.
Administering a lipid that mediates inflammation reduced chronic inflammation associated with multiple sclerosis in mouse models. Researchers found these mediator lipids are reduced in humans with multiple sclerosis.
Researchers have identified an autoantibody that appears to cause schizophrenia in some individuals. The findings add to the growing body of evidence that schizophrenia could have an autoimmune component.