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autoimmune diseases

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·October 17, 2019·4 min read

First evidence of immune response targeting brain cells in autism

Examining postmortem brains of ASD patients, researchers discover an accumulation of immune cells surrounding blood vessels in the brain. They also found blebs accumulating around blood vessels that contained astrocyte debris. The findings suggest autism may be an autoimmune disorder.

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·December 4, 2019·3 min read

The gut may be involved in the development of multiple sclerosis

Increased levels of Smad7 in T-cells is linked to multiple sclerosis-like symptoms in mice. In the intestines, the T-cells were more frequently activated and migrated to the central nervous system, where they triggered inflammation. Similar activation was seen in human patients with multiple sclerosis. The findings provide further evidence that multiple sclerosis may start in the intestines and spread via the CNS.

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·January 23, 2019·5 min read

Shedding Light on Brain Cell Changes in Multiple Sclerosis

A new study sheds light on brain cells implicated in multiple sclerosis. Researchers found there are several types of oligodendrocytes, and the ratio of these cells differ significantly in those with MS. The findings could help develop new targeted treatments for progressive multiple sclerosis.

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·October 16, 2019·4 min read

Frontotemporal dementia is associated with alterations in immune system function

Researchers discovered increased inflammatory activity in a subgroup of patients with frontotemporal dementia. The increased inflammation was indicated by elevated levels of cytokines known to increase inflammatory response and decreased levels of IL-10, which reduces inflammation. The inflammation was associated with Parkinsonism's symptoms and rapid cognitive and functional decline. The study also revealed patients with FTD are less likely to develop cancer.

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·October 7, 2019·3 min read

Surprise contributor to multiple sclerosis identified

Oligodendrocyte progenitor cells (OPCs) actively contribute to neuroinflammation associated with multiple sclerosis.

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·December 13, 2017·3 min read

Cellular Self Digestion Process Triggers Autoimmune Disease

A new study reveals how autophagy in certain immune cells can lead to the immune system attacking the central nervous system. The findings have implications for the treatment of autoimmune diseases, like multiple sclerosis.

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·April 6, 2020·4 min read

Compound in fruit peels halts damage and spurs neuronal repair in multiple sclerosis

Ursolic acid, a compound abundant in fruit peels and some herbs, appears to decrease further neural damage and help regenerate myelin in mouse models of multiple sclerosis. Study reveals ursolic acid suppresses TH17 cells, which are one of the main drivers in the pathological autoimmune response of MS.

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·December 27, 2017·4 min read

Potential Path to Repair Nerves Damaged by Multiple Sclerosis

Findings could lead to neuroprotective treatment for MS that are tailored to repair damage cause by the disease.

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·July 11, 2019·4 min read

Are the ‘viral’ agents of MS, ALS and schizophrenia buried in our genome?

Retroviruses may be a missing causal link in diseases like ALS, multiple sclerosis and schizophrenia.

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·June 5, 2019·3 min read

Nanotechnology treatment reverses multiple sclerosis in mice

Extracting nanosized exosomes from bone marrow stem cells and injecting them into mice, researchers reverse symptoms of multiple sclerosis.

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·September 18, 2020·3 min read

Immune System May Have Another Job, Combatting Depression

Gamma interferons, a type of immune cell that induces and modulates several immune system responses, may also play a role in preventing depression.

Featured Genetics Neurology

·January 23, 2019·4 min read

Old Cells Repair Damage in Brains of Those with Multiple Sclerosis

Researchers discovered oligodendrocyte neurogenesis is limited in the brains of patients with Multiple Sclerosis. However, oligodendrocytes that survive the autoimmune attack associated with MS may be able to form new myelin.

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