A new study reveals how autophagy in certain immune cells can lead to the immune system attacking the central nervous system. The findings have implications for the treatment of autoimmune diseases, like multiple sclerosis.
A study in mouse models of multiple sclerosis demonstrates a compound called sobetirome promotes remyelination, and a derivative of the compound can penetrate the blood-brain barrier to enable a tenfold increase in infiltration to the CNS. Researchers are confident their research will translate from mice into humans, providing a new avenue of treatment for MS.
Researchers report RIPK3 appears to protect brain cells during West Nile virus infection.
Study finds no association between mineral levels or dietary mineral intake and an increased risk of multiple sclerosis.
Study reveals mice with antibody-induced rheumatoid arthritis went on to develop spinal lesions similar to those associated with axial spondyloarthritis.
Non-invasive vagus nerve stimulation reduces inflammation and improves symptoms for those suffering from rheumatoid arthritis. The simulation technique helps inhibit the production of cytokines and reduces inflammatory response.
Mice bred to be germ-free, and those treated with antibiotics showed a significant reduction in the ability to learn that a threatening danger was no longer present. Sequencing the RNA of microglia in the brains of the animals reveals altered gene expression in the immune cells, which play a role in remodeling how neurons connect during the learning process. Restoring the gut microbiota reverse the learning problems.
Reprogramming lymph nodes could help to 'turn off' harmful immune attacks that occur in Multiple Sclerosis while keeping the immune system intact, a new study reports.
Some of the T cell epitopes targeting myelin in monkeys were the same as those found in humans. Researchers say linking these specific cells opens the doors to developing antiviral therapies that could be useful to treat newly diagnosed cases of MS in humans.
Researchers discovered increased inflammatory activity in a subgroup of patients with frontotemporal dementia. The increased inflammation was indicated by elevated levels of cytokines known to increase inflammatory response and decreased levels of IL-10, which reduces inflammation. The inflammation was associated with Parkinsonism's symptoms and rapid cognitive and functional decline. The study also revealed patients with FTD are less likely to develop cancer.
A new study reports people can show early symptoms of multiple sclerosis up to five years before full onset of the disease.
Patients with RRMS who took the pregnancy hormone estriol in combination with their regular medication were able to avoid relapse, a new study reports.
