Poor sleep and inadequate oxygen supply associated with obstructive sleep apnea appears to affect cytokines. This could explain the link between OSA and an increased risk of autoimmune disorders, such as rheumatoid arthritis.
TEPP-46, a drug developed for the treatment of cancer and showed promise for the treatment of multiple sclerosis, could make MS symptoms worse, a new study reports. The drug appears to redirect inflammation away from the spinal cord and directly into the brain.
A new intranasal delivery system shows promise in reducing neuroinflammation and slowing the progression of multiple sclerosis.
By fusing a cytokine to a blood protein, researchers have developed a new therapy to help treat multiple sclerosis.
Gamma interferons, a type of immune cell that induces and modulates several immune system responses, may also play a role in preventing depression.
Women who have been pregnant were diagnosed with their first multiple sclerosis symptoms, on average, 3.3 years later than women with MS who had never become pregnant.
Specific combinations of microorganisms in the gut can worsen symptoms of multiple sclerosis in mouse models of the autoimmune disease.
Decreasing the amount of Reelin significantly protected against disease symptoms and promoted recovery in symptomatic animal models of multiple sclerosis. Reelin levels appear to correlate with MS severity and stages. Researchers report lowering levels of the protein could be a potential avenue of treatment for the autoimmune disorder.
Human iPSCs transplanted into animal models of multiple sclerosis help repair cell damage and restore function.
A new study reveals why women are more likely to develop autoimmune conditions like lupus and Sjögren's syndrome, and men are more likely to develop schizophrenia. Researchers implicated the C4 gene in sex-based risk factors for autoimmune and psychiatric disorders.
T cells that react to alpha-synuclein are most abundant in the early stages of Parkinson's disease but tend to disappear as the disease progresses. Signs of autoimmunity can appear in Parkinson's patients up to ten years before a diagnosis of the neurodegenerative disease. The detection of T cell response could be an early biomarker for Parkinson's, long before the physical symptoms begin to manifest.
Ursolic acid, a compound abundant in fruit peels and some herbs, appears to decrease further neural damage and help regenerate myelin in mouse models of multiple sclerosis. Study reveals ursolic acid suppresses TH17 cells, which are one of the main drivers in the pathological autoimmune response of MS.
