In rheumatoid arthritis, inflammation in one joint is transmitted to other joints via the sensory neuron connections in the spinal cord, leading to inflammation in the other joints. Inflammation in one joint led to an increase in ATP in other joints, which triggered an increase of a signaling molecule that resulted in inflammation. Blocking the pathway reduced the spread of inflammation.
Embryonic damage caused by autoantibodies is implicated in a range of behavioral and psychological disorders, including schizophrenia, autism, and ADHD.
A key finding in the origins of lupus has been discovered. In those with systemic lupus erythematosus, B cells are abnormally activated. This results in the production of antibodies which react against the patient's own tissue, causing a range of symptoms including rashes, joint pain, and fatigue.
Researchers have identified a new biomarker for spinal cord and brain inflammation.
Researchers discover brain like activity in the immune system. The Nature study reveals T cells in the immune system transfer dopamine to B cells, providing motivation for these cells to produce antibodies and battle infection. The researchers hope their findings will help develop treatments to make immune response to vaccines and infections faster, and slow autoimmune conditions.
A rare autoimmune disorder popularized by the autobiography and movie "Brain on Fire" is triggered by an attack on NMDA receptors. The disease occurs when antibodies attack NMDA receptors in the brain, leading to memory loss, intellectual changes, seizures, and death.
A new study reveals how autophagy in certain immune cells can lead to the immune system attacking the central nervous system. The findings have implications for the treatment of autoimmune diseases, like multiple sclerosis.