A study in mouse models of multiple sclerosis demonstrates a compound called sobetirome promotes remyelination, and a derivative of the compound can penetrate the blood-brain barrier to enable a tenfold increase in infiltration to the CNS. Researchers are confident their research will translate from mice into humans, providing a new avenue of treatment for MS.
Researchers have discovered how the body is able to initiate repair mechanisms which can limit the extent of damage to the myelin sheath. The findings could help with the development of new therapies for multiple sclerosis.
Study finds signs of IgA antibodies in the cerebrospinal fluid of patients with multiple sclerosis during a flare-up of the disease, but not when the patients are in remission. The findings suggest gut immune cells are involved in relapse episodes of multiple sclerosis.
An experimental treatment can generate immune cells that migrate to the brain and prevent attacks against myelin, allowing mice the ability to regain walking skills.
In uveitis, microglia facilitates the entry of inflammatory immune cells into the retina, enabling the host immune responses to attack cells not normally recognized by the immune system.