Neuroimaging study reveals teens with more gray matter in the caudate nucleus and left cerebellum were at increased risk of problem alcohol use over time. The findings reinforce the idea that brain structure differences may contribute to both psychiatric and substance use disorders.
Using a novel imaging technique, researchers produce a whole mouse brain atlas, which reveals how alcohol addiction, and abstinence, alter the functional architecture of the brain.
Men with alcohol use disorder have diminished brain activity in areas associated with emotional processing, memory and social processing, compared to women with AUD. The findings may lead to gender-specific treatments to help relieve addition to alcohol.
Teenage binge drinking is linked to altered gene expression in the brain, specifically the central nucleus of the amygdala. Adolescent rats exposed to alcohol had increased levels of miR-137, resulting in lower expression of proteins essential for healthy neuron growth. During adulthood, these rats displayed higher levels of anxiety and an increased preference for alcohol consumption.
Study reveals a previously unrecognized family connection to alcohol use disorder, the drinking habits of a person's in-laws. People married to those who experienced parental alcohol misuse as a child are more likely to develop an addiction to alcohol, even if the spouse has no history of a personal battle with alcohol use.
Researchers hypothesize vitamin B1 (thiamine) deficiency may play a significant role in dementia associated with alcohol use disorder. It is known iron deposits in the brain contribute to neurodegenerative diseases. Those with AUD have elevated levels of both iron in their blood and thiamine deficiency. Thiamine is vital for maintaining the blood-brain barrier. Thiamine deficiency associated with AUD disrupts the integrity of the BBB, allowing for more iron deposits within the brain and leading to oxidative tissue damage.
Contrary to popular belief that brain changes begin to normalize immediately after ceasing alcohol consumption, a new study reveals damage to the brain continues during the first weeks of abstinence.
A single shot of ketamine administered to heavy drinkers following reactivation of their drinking memories led to a rapid decrease in the urge to drink. The effect lasted for over nine months.
Genome-wide study identifies five novel alcohol use risk loci which can pass on the risk of developing alcohol abuse disorder from parents to children.