Brain organoids can be used to study molecular mechanisms that drive brain aging and neurodegenerative disorders. The mini-brains allow for the testing of molecules that could become potential therapeutic treatment options for neurodegenerative diseases.
Researchers studying the cause of A-T disease believe their findings could provide new clues to understanding neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
A new drug could help increase the effectiveness of radiation therapy for patients with glioblastoma multiforme, the most deadly form of brain cancer. The ATM kinase inhibitor, in combination with radiation therapy, helped significantly extend survival rates in mouse models of GBM.
Researchers use induced pluripotent stem cells to advance disease-in-a-dish modeling of ataxia telangiectasia, a rare genetic disorder associated with progressive loss of function in the cerebellum. Their discovery shows the positive effects of drugs that may lead to effective new treatments for the neurodegenerative disease.