Stem cell study reveals astrocytes carrying the Alzheimer's associated APOE4 gene release more cholesterol than those carrying the APOE3 gene. Findings shed light on how different versions of the APOE gene in astrocytes influence amyloid-beta production and how the oversupply of cholesterol associated with APOE4 astrocytes may promote amyloid-beta formation in Alzheimer's patients.
Cholesterol produced by astrocytes in the brain is required for the production of amyloid-beta. The findings shed light on how and why amyloid-beta forms, and may explain why genes associated with cholesterol have been implicated as risk factors for Alzheimer's disease.
Almost half of the identified human accelerated regions of the genome appear to act as neurodevelopment enhancers, researchers say. The findings shed new light on the genetic basis of human evolution.
Ketamine and exposure to 60-hertz flickering light show promise as a potentially new, non-invasive therapy to help rejuvenate the aging brain.
Study reveals the role astrocytes play in the crucial closing period of brain plasticity following birth. The findings could help in the development of strategies to reintroduce plasticity in the adult brain.
A new study reveals humans and mice have significant differences in how oxidative stress and inflammation trigger immune response genes in astrocytes. Researchers suggest lab models of neurodegeneration should incorporate specially engineered mouse models with lower resistance to oxidative stress, rendering them more human-like.
The hepaCAM protein plays a critical role in the communication and coordination of astrocytes as they build synapses. The findings shed new light on potential biological mechanisms behind ASD and epilepsy.
Secondary infections and novel inflammatory events, even ones that occur external to the brain, amplify the brain's immune response and detrimentally impact cognition in mouse models of Alzheimer's disease.
The effects of intoxication, such as slurred speech and poor coordination, are a result of the breakdown of alcohol products in the brain and not the liver.
Astrocytes help transition the brain from a highly plastic state to one that is more stable.