Study reveals the disruptions in prenatal neurogenesis can increase the risk of autism spectrum disorder. Findings also reveal estrogen can protect against the disruption of neurogenesis and steer the embryonic brain on the course of normal development.
CYFIP1 plays a key role in the damaging effects of 15q11.2 deletion. When CYFIP1 is missing, myelin abnormalities occur. The findings shed light on how psychiatric disorders, such as schizophrenia and autism, may develop.
Simulation neurons found in the amygdala allow animals to reconstruct the mental state of social partners and predict intentions. Dysfunction in these newly identified neurons may be involved in disorders associated with social behavioral problems, such as autism and social anxiety.
A new study in Scientific Reports finds evidence from MRI scans suggests Neanderthal derived genetic variations affect how the brains of modern humans work. Findings may shed light on specific deficits seen in ASD and schizophrenia, researchers believe.
A study of more than 50,000 patients with bipolar disorder in 14 countries helped researchers identify 20 new genetic risk factors for bipolar disorder. Eight of the genes also had an association with an increased risk for schizophrenia. ASD and anorexia, it was discovered, also had genetic ties to bipolar depression.
Mutations to the EGR1 gene disrupt social behaviors in zebrafish models of ASD. Additionally, the mutation disrupts dopamine signaling from specific neurons, contributing to mood and social behavior disorders.