Apoptosis plays a critical role in brain development as it influences the thickness of layers in the cerebral cortex, variety, and layer cell density. Alterations in how cells perform division and apoptosis lead to the development of abnormal cortical structures as seen in a variety of neurodevelopmental disorders, including autism.
University of Texas researchers report neurons in the mouse brain tend to surge at the equivalent of human age 40. During this period, interleukin33 also surges in healthy mice. In those lacking the gene, neurodegeneration occurred, eventually resulting in dementia.
Dysfunction of the Golgi apparatus is associated with axatia and developmental delays.
Increasing SIRT3 levels with a ketone rich diet may help protect GABAergic interneurons and delay the onset of Alzheimer's disease.
Chronic stress causes autophagy in adult hippocampal neural stem cells. This results in a decline of hippocampal neurogenesis. Cognitive deficits and mood disorders that arise as a result of chronic stress are a result of autophagic death of hippocampal neural stem cells.
Zaheera Shabbir comments on how some researchers are trying to treat neurodegenerative disorders by halting apoptosis.
Researchers report a lifelong accumulation of amyloid plaques in the brain could contribute to Alzheimer's disease.
A highly toxic form of amyloid beta disrupts the normal function of mitochondria, researchers report.