According to a new study, two genetic variants associated with Alzheimer's disease have been more specifically linked to brain atrophy that is characteristic of the disease.
Microglia that express the Alzheimer's associated APOE4 genetic variant are unable to effectively metabolize lipids. This causes lipids to build up, promoting inflammation and preventing effective neurotransmission.
Researchers report the results of MRI scans and psychological testing show marked improvements in memory for ten Alzheimer's patients following treatments with programmatic and personalized therapy.
Genetic analysis of almost 4,300 samples reveals a link between the appearance of amyloid deposits, APOE, and a novel gene called RBFOX1. Lower levels of RBFOX1 in the brain appear to be associated with increased amyloid and global cognitive decline over a person's lifetime.