Children with the APOE E4 gene perform lower on verbal and general IQ tests than their peers without the genetic risk factor. APOE E4 is a genetic risk factor for Alzheimer's disease. The study suggests the effects of the gene manifests before adulthood and could be the earliest biomarker for later vulnerability to Alzheimer's disease.
Post mortem examinations of brain tissue from Alzheimer's patients revealed synapses contained clumps of clusterin, in addition to amyloid beta. The clumps were more abundant in those with genetic risk factors from Alzheimer's disease.
Researchers have successfully neutralized a genetic risk factor found in up to 80% of Alzheimer's patients. The ability to neutralize ApoE4 could help in the development of a vaccine, as well as other therapeutics, for late onset Alzheimer's.
Researchers have identified cognitive subgroups related to genetic differences in Alzheimer's patients. The findings, researchers say, could open the door for more personalized treatments of the neurodegenerative disease.
A new study reveals carriers of the ApoE4 gene who have chronic inflammation are more likely to develop Alzheimer's disease.
A new study looks at the possible causal link between the herpes virus and Alzheimer's disease. Researchers report antiviral drugs significantly reduce the risk of developing dementia in patients with severe herpes infections.
According to researchers, children who carry the APOE4 gene and who are exposed to air pollution have higher behavior problem scores and their attention capacity was slower to develop.
A new study has linked the APOE4 gene to mental health issues some people face following TBI. Researchers report people with the APOE4 gene had significantly higher scores for depression, PTSD and anxiety following TBI than those without the genetic variant.