ApoE4

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ApoE4

·February 11, 2021·5 min read

Spinal Fluid of People With Alzheimer’s Risk Gene Signals Inflammation

People with the APOE4 genetic risk factor for Alzheimer's disease also have lower levels of the CRP inflammatory molecules in their spinal fluid. Researchers speculate these inflammatory molecules may be accumulating in the brain and causing damage, rather than floating freely in cerebrospinal fluid.

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Featured Genetics Neurology Neuroscience

·February 4, 2021·4 min read

The Link Between ‘Alzheimer’s Gene’ and COVID-19

ApoE4, a gene associated with an increased risk of Alzheimer's disease, also appears to increase susceptibility and the severity of COVID-19. SARS-CoV-2, the virus responsible for coronavirus, increased susceptibility to COVID-19 in ApoE4 neurons and astrocytes in brain organoid models.

Featured Genetics Neurology Open Neuroscience Articles

·October 6, 2020·6 min read

Alzheimer’s Risk Gene Disrupts Endocytosis, but Another Disease-Linked Gene Could Help

The Alzheimer's risk gene ApoE4 hampers the process of endocytosis in astrocytes.

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Featured Genetics Neurology Open Neuroscience Articles

·July 18, 2020·5 min read

Adults With Alzheimer’s Risk Factors Show Subtle Alterations in Brain Networks Despite Normal Cognition

APOEe4, a gene associated with Alzheimer's disease risk, doesn't appear to directly affect memory performance or brain activity in older adults without cognitive impairment. However, the gene does seem to influence brain regions and systems that older at-risk adults activate to support successful memory recall.

Featured Genetics Neurology

·June 23, 2020·5 min read

New gene may drive earliest brain changes in Alzheimer’s

Genetic analysis of almost 4,300 samples reveals a link between the appearance of amyloid deposits, APOE, and a novel gene called RBFOX1. Lower levels of RBFOX1 in the brain appear to be associated with increased amyloid and global cognitive decline over a person's lifetime.

Featured Genetics Neurology Neuroscience

·April 29, 2020·4 min read

APOE4 triggers early breakdowns in the blood-brain barrier

APOE4, a gene implicated as a risk factor for Alzheimer's disease, triggers leaks in the blood-brain barrier. The damage to capillaries APOE4 causes correlates with increased levels of cyclophilin, a protein that causes the inflammation that is a signature of early Alzheimer's.

Featured Genetics Neurology Neuroscience

·April 13, 2020·7 min read

Gene variant staves off Alzheimer’s in some people

Carriers of one copy of the longevity associated klotho gene reduces Alzheimer's risks by 30% for those with genetic risk factors for the neurodegenerative disease.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·September 16, 2019·4 min read

Alzheimer’s disease risk gene APOE4 impairs function of brain immune cells

APOE4 increases the inflammatory response of human microglia while reducing cellular migration. The gene also impairs the metabolic activity of the immune cells. The findings show APOE4 has a profound impact on the basic functions of microglia.

Featured Neurology Neuroscience

·September 13, 2019·3 min read

What multilingual nuns can tell us about dementia

While being multilingual did not delay the onset of dementia for those at risk, nuns who spoke four or more languages were significantly less likely to develop dementia than those who spoke just one language.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·August 22, 2019·4 min read

Carriers of Alzheimer’s genetic marker have greater difficulty harnessing past knowledge

Middle-aged people with the Alzheimer's related APOE4 gene have a harder time accessing recently acquired knowledge, even when they show no symptoms of memory decline.

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Featured Neurology Neuroscience

·August 2, 2019·6 min read

Blood test 94% accurate at identifying Alzheimer’s before symptoms appear

A new blood test for Alzheimer's disease is up-to 94% accurate at predicting dementia before symptoms appear. The test's accuracy is increased when genetic predisposition and age are taken into account. The new test may eventually replace PET neuroimaging, currently considered the gold standard, for early detection of Alzheimer's.

Featured Genetics Neurology Neuroscience

·July 20, 2019·3 min read

Lower childhood IQ linked to Alzheimer’s later in life

Children with the APOE E4 gene perform lower on verbal and general IQ tests than their peers without the genetic risk factor. APOE E4 is a genetic risk factor for Alzheimer's disease. The study suggests the effects of the gene manifests before adulthood and could be the earliest biomarker for later vulnerability to Alzheimer's disease.

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