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ApoE4

Featured Genetics Neurology Neuroscience

·September 30, 2024·5 min read

Genetic Variants Linked to Alzheimer’s Trigger Inflammation in Females

Researchers have discovered that two genetic variants, APOE4 and TREM2 R47H, together cause a harmful inflammatory response in brain immune cells, particularly in females. This response leads to more severe brain damage, including tau protein clumps, which are linked to Alzheimer’s disease progression.

Featured Genetics Neurology Neuroscience

·May 6, 2024·5 min read

APOE4 Gene Doubles Up Alzheimer’s Risk

A novel study sheds new light on the link between the APOE4 gene and Alzheimer’s disease. The study reveals that over 95% of individuals over 65 who have two copies of the APOE4 gene exhibit biological markers of Alzheimer's in the brain or through cerebrospinal fluid and PET scans.

Featured Genetics Neurology Neuroscience

·July 26, 2023·3 min read

Early Odor Detection Loss Linked to Alzheimer’s Gene Variant

Individuals carrying a gene variant associated with Alzheimer's disease, APOE e4, may experience early loss in their ability to detect odors, hinting at future cognitive challenges. The study employed an at-home survey to test over 865 people's sense of smell and cognitive skills at five-year intervals.

Featured Genetics Neurology Neuroscience

·April 14, 2023·3 min read

Missing Link Between Risk Genes Associated With Alzheimer’s Disease Discovered

Scientists have discovered a connection between two types of Alzheimer's disease, shedding light on how the most common form of the disease is linked to a rarer form. The discovery could help researchers develop new treatments for Alzheimer's, which affects millions of people worldwide.

Featured Neurology Neuroscience

·March 1, 2023·4 min read

Taking Vitamin D Could Help Prevent Dementia

Taking a vitamin D supplement daily may help stave off dementia in older adults, a new study reports. Researchers found taking vitamin D was associated with adults living dementia free for longer, and there were 40% fewer cases of dementia reported in those who frequently took vitamin D supplements. The effects were significantly greater in women than men.

Featured Genetics Neurology Neuroscience

·January 14, 2023·5 min read

Hormone Replacement Therapy Could Ward off Alzheimer’s Among At-Risk Women

Hormone replacement therapy (HRT) use was associated with better cognition, memory, and larger brain volume in women who carry the Alzheimer's associated APOE4 genetic variant.

This shows tissue samples from the study

Featured Genetics Neurology Neuroscience

·November 16, 2022·7 min read

Alzheimer’s Risk Gene Undermines Insulation of Brain’s ‘Wiring’

When people carry the Alzheimer's associated APOE4 gene, oligodendrocytes fail to transport fatty molecules to wrap neurons that make brain circuitry connections. This deficit of myelin may contribute to the pathology and symptoms of Alzheimer's disease.

Featured Neurology Neuroscience Open Neuroscience Articles

·November 16, 2022·6 min read

Why Alzheimer’s Disease Damages Certain Parts of the Brain

Parts of the brain in which the APOE gene is most active are the areas that sustain the most damage associated with Alzheimer's disease.

Featured Neurology Neuroscience

·October 5, 2022·3 min read

Omega-3’s Linked to Improved Brain Structure and Cognition at Midlife

Boosting omega-3 fatty acid intake helps to preserve brain health and improve cognition in middle age, a new study reports. For those with the Alzheimer's associated APOE4 gene, omega-3 fatty acid intake was associated with greater hippocampal volume and less small vessel disease.

Featured Genetics Neuroscience

·September 21, 2022·6 min read

Common Alzheimer’s Gene Variant Linked to COVID Mortality

Mice with the Alzheimer's disease-associated APOE4 and the APOE2 genes were more likely to die from COVID-19 than those with the APOE3 gene. Those with APOE4 and APOE2 genes had more virus replication in the lungs, higher inflammation, and increased tissue damage following coronavirus infection.

Featured Neurology Neuroscience

·August 4, 2022·6 min read

How Microglia Contribute to Alzheimer’s Disease

Microglia that express the Alzheimer's associated APOE4 genetic variant are unable to effectively metabolize lipids. This causes lipids to build up, promoting inflammation and preventing effective neurotransmission.

Featured Genetics Neurology Visual Neuroscience

·July 26, 2022·4 min read

Changes in the Retina Can Be Linked to Parts of the Brain of Healthy Subjects at Risk of Alzheimer’s

In cognitively healthy people with a genetic risk for Alzheimer's, retinal changes have been associated with alterations in the entorhinal cortex, hippocampus, and lingual gyrus. Researchers say retinal changes can be used to track changes in brain structures associated with Alzheimer's in those with genetic risk factors.