Psychopathy is associated with altered expression of genes and immune responses related to molecular pathways. In neurons, the up-regulation of PRL10P9 and ZNF132 and down-regulation of CDG5 and OPRD1 were linked to psychopathic behaviors. The genetic expression explained up to 92% of the variance of psychopathic symptoms. Researchers speculated these genes may be relevant to the lack of empathy and emotional callousness associated with psychopathy, as previous studies have linked a number of these genes to ASD and problematic social behaviors.
··5 min read
Differences in Brain Structure Between Siblings Make Some More Susceptible to Developing Severe Antisocial Behavior
Study found structural differences in the prefrontal cortex and brain areas associated with empathy and cognitive control, between siblings where one displayed antisocial behaviors and the other did not.