Researchers report a blockade of D2 receptors in interneurons can increase acetylcholine signaling above threshold on neighboring neurons, resulting in motor abnormalities.
Typical interventions for schizophrenia do not improve long-term outcomes, even when administered early, a new study reports.
Flies without the Rim gene or cac Cav2 channel function displayed numerous cognitive and behavioral deficits associated with schizophrenia, and had reductions in synaptic growth and neural calcium transients. Exposing the flies with Rim deficits to the common antipsychotic haloperidol reduced some of the schizophrenia-related behavioral symptoms.
According to researchers, a mutation in a gene associated with brain development may dispose people to various psychiatric illnesses as it reduces synapse numbers. Lithium may help to restore some of the synapses.
During memory tasks, people with psychosis have different patterns of activity in the prefrontal and mediotemporal brain areas compared to those without the disorder. When exposed to cannabidiol (CBD), the activity of the brain areas became more like those seen in the controls for people with psychosis. Patients reported a decrease in symptoms of psychosis following one dose of CBD. Researchers stress that no definitive conclusions could be made about the effectiveness of CBD use over a sustained period.
Researchers say 80% of people taking antipsychotics to manage schizophrenia or bipolar disorder experience considerable weight gain. Some patients report up to 33kg of weight gain following taking antipsychotic medications. A new study aims to explore ways of managing weight gain for patients taking antipsychotics.
Researchers provide possible new insights into psychiatric disorders such as schizophrenia.
A new study reports many people with intellectual disabilities are being prescribed antipsychotic medications even though they have no record of mental illness.
According to researchers, fMRI brain scans may be used to predict a patient's responsiveness to antipsychotic medications.
According to a new study, lithium appears to be safe and effective in treating bipolar disorder in children, at least in the short term.