Researchers have uncovered the structure of psychedelic compounds when they actively bind to the 5-HT2A serotonin receptor on the surface of brain cells. The discovery could lead to the exploration of more precise compounds that offer the therapeutic effects of psychedelics for mental health disorders, but without the hallucinations.
Activity of the c-Fos gene begins the increase on the ninth day of exposure to antidepressants. By day 14, mice showed behavioral changes associated with SSRI use. This may explain why suicide rates drop after nine days of treatment, and symptoms of depression improve after three weeks.
Using patient-derived adult stem cells, researchers found fish oil created an antidepressant response.
Ketamine increases the number of serotonin 1B receptors. Ketamine binds to serotonin 1B receptors, reducing the release of serotonin and increasing the release of dopamine.
The SSRI sertraline (Zoloft), if taken while pregnant, can result in birth defects caused by the drug damaging a cell's genetic information. Researchers report one potential way to counter the effect is with specific antioxidants.
Increased levels of serotonin transporters in the amygdala may explain why some people are more prone to anxiety than others.
While it is well-known antidepressants are effective at treating those with depression, a new study reports the medications may be beneficial as a preventative measure for those with a risk factor for depressive disorders.
Children exposed to SSRI antidepressants in utero had an increased risk of experiencing language and cognitive deficits in kindergarten.
Brain connections strengthened with treatment from fast-acting antidepressants, such as ketamine, are consolidated during deep sleep. Researchers propose rapid antidepressant treatments share the ability to regulate both synaptic potentiation and homeostatic mechanisms, which may contribute to how the brain reorganizes its activity to defeat depression.
The GPR56 protein has been implicated in the biology of depression and a person's response to antidepressants.
A new substance named Lu AF60097 may help reduce side effects from tricyclic antidepressants in those with severe depression.
Chronic stress can affect a person's health and mental well being. Due to the COVID-19 virus, chronic stress is on the rise worldwide. Researchers examine the general and psychological health implications of chronic stress and suggest some methods we can adopt to keep our stress levels in check.