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antidepressants

·October 30, 2025·6 min read

Common Antidepressant Eases Core Symptoms Within Two Weeks

A new analysis of the PANDA clinical trial reveals that sertraline, one of the most prescribed antidepressants, improves key emotional symptoms of depression—such as sadness, self-loathing, and suicidal thoughts—within just two weeks of treatment. Using network analysis to assess individual symptoms, researchers found that the drug also eased anxiety early on, while somatic effects like fatigue and low libido appeared but later stabilized.

Featured Neuroscience Psychology

·October 22, 2025·8 min read

Ketamine Fails to Outperform Placebo in Major Depression Trial

A large randomized and blinded clinical trial has found no additional benefit of repeated ketamine infusions over standard inpatient care for treating major depression. The study compared ketamine with a psychoactive placebo and found no meaningful differences in objective or self-reported depression scores, cognition, or quality of life.

This shows a woman, hearts, a brain, and brain waves.

Featured Neuroscience Psychology

·October 13, 2025·6 min read

EEG Test May Reveal Who Loses Libido on Antidepressants

A new study reveals that serotonin levels in the brain, measured using a simple EEG-based test, can predict who will experience sexual side effects from SSRI antidepressants. Researchers found that people with higher serotonin activity before treatment were significantly more likely to have difficulty reaching orgasm during antidepressant use.

This is a visual representation of the 5-HT1A serotonin receptor.

Featured Neuroscience Psychology

·August 2, 2025·6 min read

Fat Molecule May Control How You Feel Emotion

Scientists have uncovered how the brain’s 5-HT1A serotonin receptor—vital in mood regulation—functions at the molecular level. This receptor, a common target of antidepressants and psychedelics, prefers certain signaling pathways no matter the drug, but drugs can still vary in how strongly they activate them.

Featured Neuroscience Psychology

·July 10, 2025·7 min read

Most Antidepressant Users Don’t Face Severe Withdrawal

The largest review of antidepressant withdrawal studies shows most people don’t experience severe symptoms when stopping these medications. Analyzing data from nearly 18,000 participants, researchers found the most common withdrawal symptoms were mild, including dizziness, nausea, and nervousness.

Featured Neurology Neuroscience

·May 30, 2025·4 min read

SSRIs Restore Brain Function in Alzheimer’s

A new study suggests that SSRIs, commonly prescribed antidepressants, may reduce biological markers of Alzheimer’s disease. In a cohort of 191 individuals, AD patients on SSRIs had lower levels of plasma phosphorylated tau-181, a key indicator of disease severity.

Featured Neuroscience Psychology

·May 24, 2025·4 min read

Boosting Ketamine’s Antidepressant Effects to Last Two Months

Ketamine is a fast-acting antidepressant that can relieve symptoms of major depressive disorder (MDD) within hours, even in treatment-resistant cases. However, its effects typically last only a week, and frequent dosing poses risks like dissociation or addiction.

Neuroscience

·May 22, 2025·6 min read

Long-Term Antidepressant Use Tied to Tougher Withdrawal Symptoms

A new study finds that people who have taken antidepressants for more than two years are significantly more likely to experience withdrawal symptoms when stopping the medication. The longer someone used antidepressants, the more severe and prolonged the symptoms became, with 64% of long-term users reporting moderate or severe withdrawal.

Featured Neuroscience Psychology

·May 7, 2025·8 min read

SSRI Exposure in the Womb May Rewire Brain Circuits

New research suggests that prenatal exposure to SSRIs may alter brain development in ways that increase the risk of depression and anxiety later in life. Using mice and human data, scientists found that early-life SSRI exposure heightened activity in brain fear circuits, a pattern not observed in offspring of depressed mothers who did not take SSRIs.

Featured Neuroscience Psychology

·April 23, 2025·6 min read

Can Brain Scans Tell Which Antidepressant Will Work for You?

A new study shows that brain connectivity patterns, especially in the dorsal anterior cingulate cortex, can help predict how patients with major depressive disorder (MDD) will respond to antidepressants. By combining brain imaging with clinical data, researchers developed machine learning models that accurately predicted treatment outcomes across two large trials.

Featured Neuroscience Psychology

·April 4, 2025·3 min read

How Psilocybin Lifts Mood Without the Hallucinogenic Trip

Researchers have uncovered two key brain mechanisms—specific neurons and a serotonin receptor—that help explain how psilocybin produces long-lasting antidepressant effects. Their study identified pyramidal tract neurons in the medial frontal cortex and the serotonin 5-HT2A receptor as essential to the therapeutic action of psilocybin.

Featured Neuroscience Psychology

·February 25, 2025·3 min read

SSRIs May Speed Up Cognitive Decline

A new study based on data from 18,740 dementia patients suggests that antidepressants may accelerate cognitive decline. Researchers found that patients taking antidepressants, particularly SSRIs like escitalopram, citalopram, and sertraline, experienced faster deterioration compared to those not on medication.