New studies find a drug designed to combat the gene that causes SCA2 could also be beneficial in the fight against ALS.
The TBK1 gene regulates the disease progression of ALS in mouse models of the neurodegenerative disease. Loss of the TBK1 gene in motor neurons increases SOD1 aggregation and accelerates the onset of the disease.
Transgenic mice carrying a gene variant found in one third of people with ALS have faster disease progression and die sooner than those with a standard genetic model of the disease, a new study reports.
Schwann cells help protect nerves against blood clotting factors that cause degeneration, researchers report.
Researchers have isolated a molecule that may be under-produced in the gut of those with ALS. Using mouse models of the disease, researchers identified 11 microbial strains that became altered as the disease progressed, or before the development of symptoms.
WUSTL researchers have converted skin cells into motor neurons without going through the stem cell state. The new technique could help in the development of devastating neurodegenerative diseases, like ALS, that affect motor neurons.
Researchers have identified a key instigator of neural damage in people with ALS.