Researchers discover an abnormal protein that accumulates in the brains of patients affected with ALS and frontotemporal dementia. The findings have uncovered a potentially new therapeutic target and biomarker that would allow clinicians to confirm diagnosis of the diseases.
Transgenic mice carrying a gene variant found in one third of people with ALS have faster disease progression and die sooner than those with a standard genetic model of the disease, a new study reports.
Researchers report microglia is critical for neuronal survival in ALS.
While evidence suggests pathological proteins linked to the onset and progression of neurodegenerative disorders are capable of spreading from cell-to-cell within the brains of affected individuals, new research shows no evidence to support concerns that these abnormal disease proteins are “infectious” or transmitted from animals to humans or from one person to another.
Researchers create neurons from the skin cells of ALS patients in order to "treat" a gene defect in a dish.