Researchers discover an abnormal protein that accumulates in the brains of patients affected with ALS and frontotemporal dementia. The findings have uncovered a potentially new therapeutic target and biomarker that would allow clinicians to confirm diagnosis of the diseases.
New research supports the idea that a malfunction of the TDP-43 protein plays a decisive role in the development of ALS and FTD.
A new study ties mutations in two genes to the death of nerve cells in amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases.
Using a tiny dose of the leukemia drug nilotinib, researchers halt the accumulation of toxic proteins linked to Parkinson's diseases in the brains of mice.
Researchers have identified mutations in a number of genes which could be associated with the development of spontaneously occurring cases of ALS, a progressive and fatal neurodegenerative disease in which motor neurons gradually cease to function.
Transplanting human stem cells into rat models with ALS improved survival and muscle function, according to a new study.
A new study finds slowdowns in the transport and delivery of proteins, nutrients and signaling molecules within nerve cells could contribute to the development of ALS.
Performing post-mortem staging of the brains and spinal cord tissue of patients with ALS, researchers discover the neurodegenerative disease could progress from one start point in the CNS to other regions of the brain and spinal cord.
Researchers discover four new potential biomarkers which characterize non-genetic ALS. The findings could provide new directions for diagnostics and treatment of ALS.
By reducing the expression of the SOD1 gene, ALS onset and progression is slowed, a new study suggests.