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amyotrophic lateral sclerosis

·February 3, 2023·3 min read

Features That May Make Motor Neurons Vulnerable to ALS

Study links motor neurons' large cell size and supporting structures with genes that underly vulnerability to degeneration associated with ALS.

Featured Genetics Neurology

·October 19, 2015·4 min read

ALS and Frontotemporal Dementia Linked to Nuclear Transport Problems

A new study points to a potential new target to treat neurodegenerative diseases.

Featured Neurology Neuroscience

·June 27, 2019·4 min read

Weight gain and high BMI linked to lower risk of ALS

While being overweight may be bad for your general health, researchers discovered an association with higher body mass index (BMI) and a reduced risk of developing ALS. Those with a BMI considered to be in the obese range had a 31% reduced risk of developing ALS, while those considered overweight had an 18% lower risk.

Image shows molecular structure of proteins.

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·December 31, 2015·5 min read

Study Opens New Doors for ALS Drug Discovery

Researchers pin down the structure of toxic clumps of a protein associated with a large number of ALS cases. The findings could help open the door to developing new drugs to treat the disease.

Featured Neurology Neuroscience Open Neuroscience Articles

·January 28, 2022·4 min read

Simple and Reliable ALS Diagnosis With Blood Tests

Measuring the level of neurofilaments in the blood may be a reliable biomarker for the early diagnosis of ALS.

Featured Genetics

·November 7, 2016·3 min read

New Mouse Model of ALS More Closely Mimics Human Disease

Researchers have developed a new mouse model of ALS that could help provide better understanding of the progressive nature of the disease.

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·July 11, 2019·4 min read

Are the ‘viral’ agents of MS, ALS and schizophrenia buried in our genome?

Retroviruses may be a missing causal link in diseases like ALS, multiple sclerosis and schizophrenia.

Scientists created a mouse model of ALS and FTD caused by mutations in the C9ORF72 gene. Credit: Courtesy of Petrucelli lab, Mayo Clinic, Jacksonville, Fla.

Featured Genetics

·May 22, 2015·4 min read

Scientists Create Mice with a Major Genetic Cause of ALS and FTD

Researchers believe mouse could provide a new platform for testing treatments for several neurodegenerative diseases.

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Featured Neurology Neuroscience

·March 10, 2022·4 min read

Motor Neuron Toxin Associated With ALS Identified

PolyP, an inorganic polyphosphate released by astrocytes in people with ALS and frontotemporal dementia contributes to the signature motor neuron death associated with the disease pathologies.

Featured Genetics Neurology Neuroscience

·February 11, 2023·6 min read

Large-Scale Generation of Muscle-Controlling Nerve Cells From ALS Patients

A person's sex is one of the main drivers of altered gene expression in motor neurons, regardless of whether they were derived from patients diagnosed with ALS. Male ALS stem cells generated significantly more motor neurons than the control group, however, this was not seen in female samples.

Featured Neuroscience

·November 25, 2013·3 min read

A New Kind of Genetic Switch Can Target the Activities of Just One Type of Brain Cell

Microglia plays crucial roles both in healthy and diseased brains, a new study reports.

Featured Genetics Neurology

·August 2, 2012·3 min read

Researchers Find Genetic Cause for Body Tremors

Scientists knew that mutations in the FUS gene (Fused in Sarcoma) cause amyotrophic lateral sclerosis (ALS), a disease of the nerve cells in the brain and spinal cord that control voluntary muscle movement. The researchers were successful in identifying mutations in this gene that cause Essential Tremor, and proved that the disease mechanisms for ET and ALS FUS mutations are different.

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