Hyperactive microglia immune cells may play a significant role in the development of ALS, researchers report.
Researchers reveal how proteins accumulate in the incorrect parts of brain cells in ALS, and demonstrate how it may be possible to reverse the accumulation.
Post-mortem studies of brain tissue from ALS patients reveal an abnormal form of tau is present in novel brain areas, and the tau interacts with DRP1. The tau appears to cause the brain cell's mitochondria to fragment and increase oxidative stress. Reducing tau reversed the effect, decreasing oxidative stress and mitochondrial fragmentation.
In patients with ALS, astrocytes within the brain become pro-inflammatory and tend to lose their protective function, resulting in changes in the ability to uptake glutamate.
Measuring the level of neurofilaments in the blood may be a reliable biomarker for the early diagnosis of ALS.
Mislocalization of the TDP-43 protein alters the genetic instructions for UNC13A. The findings provide a potential new therapeutic target for the treatment of ALS and frontotemporal dementia.
PolyP, an inorganic polyphosphate released by astrocytes in people with ALS and frontotemporal dementia contributes to the signature motor neuron death associated with the disease pathologies.
Study reveals an association between intestinal inflammation and the gut microbiome in the development and progression of ALS.
Researchers discovered both immune system and central nervous system dysfunction in animal models and people with ALS4, a genetic, juvenile, and slow-progressing form of ALS.
Those working in production occupations, especially those exposed to volatile organic compounds, metals, combustion pollutants, and particulate matter have a higher risk of developing ALS.
With the help of AI, researchers are developing digital biomarkers that use speech data to identify ALS and frontotemporal dementia.
Lacticaseibacillus rhamnosus HA-114, a non-commercial probiotic reduces neurodegeneration and has neuroprotective effects in lab models of ALS.
