While evidence suggests pathological proteins linked to the onset and progression of neurodegenerative disorders are capable of spreading from cell-to-cell within the brains of affected individuals, new research shows no evidence to support concerns that these abnormal disease proteins are “infectious” or transmitted from animals to humans or from one person to another.
A new finding turns one of the basics of neurobiology on its head, demonstrating that it is possible to turn one type of already differentiated neuron into another within the brain.
Efforts to treat disorders like Lou Gehrig’s disease, Paget’s disease, inclusion body myopathy and dementia will receive a considerable boost from a new research model created by UC Irvine scientists.
Professional football players in this study were three times more likely to die as a result of diseases that damage brain cells compared to the general population. A player’s risk of death from Alzheimer’s disease or ALS was almost four times higher than the general population.
By increasing the signaling activity of a protein called muscle skeletal receptor tyrosine-protein kinase (MuSK), researchers were able to keep nerve cells attached to muscle longer into the progression of the disease in a mouse model of ALS.
Scientists knew that mutations in the FUS gene (Fused in Sarcoma) cause amyotrophic lateral sclerosis (ALS), a disease of the nerve cells in the brain and spinal cord that control voluntary muscle movement. The researchers were successful in identifying mutations in this gene that cause Essential Tremor, and proved that the disease mechanisms for ET and ALS FUS mutations are different.
Researchers from the Bellvitge Biomedical Research Institute at the University of Barcelona have coordinated research into how the IDPN nitrile causes neurological syndromes similar to those of the amyotrophic lateral sclerosis (ALS), a severe neuromuscular degenerative disease.
Findings could have broad therapeutic potential for many neurodegenerative diseases. Degeneration of the axon and synapse, the slender projection through...
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Researchers discover common cause of all forms of ALS. The underlying disease process of amyotrophic lateral sclerosis (ALS and Lou Gehrig’s disease), a fatal neurodegenerative disease that paralyzes its victims, has long eluded scientists and prevented development of effective therapies. Scientists weren’t even sure all its forms actually converged into a common disease process.
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Buck Institute research in mice moves into preclinical stage; working toward human trials Lithium profoundly prevents the aggregation of toxic...
Research into amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, has lead to new information about neuronal loss...