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amyotrophic lateral scelrosis

Featured Genetics Neurology Neuroscience

·June 14, 2024·5 min read

FUS Protein Linked to FTD and ALS Spread

A new study reveals how the FUS protein aggregates and spreads in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The research shows that misfolded FUS proteins act like prions, spreading disease within the brain and exacerbating neurodegeneration. This discovery opens new avenues for therapeutic strategies targeting protein aggregate spread.

Featured Genetics Neurology Neuroscience

·March 22, 2024·7 min read

ALS and Dementia Share Molecular Links

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) share remarkably similar cellular and molecular characteristics despite their different clinical manifestations. The study analyzed RNA expression in over 620,000 cells from the motor and prefrontal cortex of 73 donors, revealing nearly identical changes in gene expression in the most vulnerable neurons across both diseases. This suggests potential therapeutic targets for ALS may also be effective for FTLD, and vice versa.

Featured Genetics Neurology Neuroscience

·March 16, 2023·5 min read

DNA Treatment Could Delay Paralysis That Strikes Nearly All Patients With ALS

DNA designer therapeutics restored levels of a protein critical to motor neuron function, restoring the activity that is impaired as a result of ALS.

This shows a brain in the style of Van Gogh

Featured Neurology Neuroscience

·March 13, 2023·4 min read

A New Immune Pathway Sheds Light on ALS

A recent study reveals that certain proteins, usually associated with inflammation and immunity, can cause damage to our neurons, contributing to ALS.

Featured Genetics Neurology Neuroscience

·November 22, 2022·5 min read

RNA-Targeting Strategy to Repair Genetic Cause of ALS and Dementia Developed

A novel compound eliminates disease-causing segments of RNA associated with ALS and dementia, and restores the health of neurons in mouse models.

Featured Genetics Neurology Neuroscience Neuroscience Videos

·April 3, 2022·5 min read

Mutations in Noncoding DNA Are Found to Protect the Brain From ALS

Mutations in the IL18RAP gene reduce inflammation and appears to protect the brain against ALS.

Featured Genetics Neurology

·April 9, 2018·6 min read

ALS and FTD Share Genetic Link

A new study links common genetic variants to both ALS and frontotemporal dementia. The findings could help in the development of treatment strategies for both disorders, researchers report.

Featured Genetics Neurology Open Neuroscience Articles

·May 15, 2017·4 min read

Stem Cell Transplants May Advance ALS Treatment By Repairing Blood-Spinal Cord Barrier

According to researchers, bone marrow stem cell transplants helped repair damage to the blood spinal cord barrier in mouse models of ALS. This helped improve motor functions and nervous system conditions.