Alzheimer’s disease

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Alzheimer’s disease

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·October 1, 2019·3 min read

A brain protein that could put the brakes on Alzheimer’s

Reducing the expression of the protein TOM1 in mouse models of Alzheimer's disease increased the pathology, exacerbated cognitive problems, and raised levels of inflammation in the brain. Restoring TOM1 reversed the effects. Findings suggest a new therapeutic target for treating dementia.

Image shows the acetylcholine pathway in the brain.

Electrophysiology Featured Neuroscience

·January 24, 2017·2 min read

A Brain Wide Chemical Signal That Enhances Memory

Acetylcholine is released in higher amounts when the brain is engaged in more challenging mental tasks, a new study reports.

Featured Neurology

·May 11, 2017·4 min read

A Closer Look at Mild Cognitive Impairment

Study reveals 46.5% of people who were diagnosed with MCI later tested as 'normal' during a follow-up assessment.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·December 29, 2021·4 min read

A Common Risk Factor for Alzheimer’s Disease May Predispose Carriers to Severe COVID-19

Carriers of the Alzheimer's associated APOE4 gene have more than double the risk of developing severe COVID-19, a new study reports. Additionally, more microscopic hemorrhages were found in the brains of APOE4 carriers who contracted coronavirus. Researchers report those with the APOE4 gene also are more susceptible to developing long-term symptoms following COVID infection, including an increased risk of mental fatigue.

Featured Neurology Neuroscience

·May 19, 2021·6 min read

A Complex Link Between Body Mass Index and Alzheimer’s

While there is an association between obesity during midlife and an increased risk of Alzheimer's disease, researchers say the link doesn't necessarily extend into later life. A new study revealed higher genetic risk for Alzheimer's and lower BMI, especially in older men, was linked to an increased risk of Alzheimer's disease and predicted the disease progression.

oligodendrocytes from alzheimer's brain tissue are shown

Deep Learning Featured Genetics Machine Learning Neurology Neuroscience Neurotech

·May 1, 2019·6 min read

A comprehensive map of how Alzheimer’s affects the brain

Axon myelination is significantly disrupted in patients with Alzheimer's disease. Researchers also found brain cells of men and women vary significantly in how their genes respond to the neurodegenerative disease.

The image shows damage to the brain in an Alzheimer's patient.

Featured Neurology

·August 14, 2013·1 min read

A Genetic Answer to the Alzheimer’s Riddle?

Researchers discover a form of CD33, which lacked a critical functional domain, correlates with a reduced risk of Alzheimer's disease.

Featured Genetics Neuroscience Open Neuroscience Articles

·September 25, 2020·5 min read

A Genetic Variant That Protects Against Alzheimer’s Promotes Immune Cell Functions

PLCG2-P522R, a genetic variant that protects against Alzheimer's disease, enhances key functions of immune cells.

Featured Neurology

·January 30, 2017·3 min read

A Glitch in ‘Gatekeeper Cells’ Slowly Suffocates the Brain

A new study reveals pericyte degeneration may influence the development of Alzheimer's disease.

This image shows astrocytes in the brain.

Featured Genetics Neuroscience

·February 18, 2016·4 min read

A Key Mechanism that Could Improve Brain Function

Astrocytes can be adjusted by neurons in response to injury and disease, a new study reports.

Image of amyloid plaques in Alzheimer's brain tissue.

Featured Neurology

·September 18, 2015·4 min read

A Major Breakthrough in Understanding of Alzheimer’s Disease Reported

A new study sheds light onto a fundamental mechanism underlying the development of Alzheimer's disease. Researchers believe the findings could lead to new forms of therapy for those living with the disease.