Reducing the expression of the protein TOM1 in mouse models of Alzheimer's disease increased the pathology, exacerbated cognitive problems, and raised levels of inflammation in the brain. Restoring TOM1 reversed the effects. Findings suggest a new therapeutic target for treating dementia.
Carriers of the Alzheimer's associated APOE4 gene have more than double the risk of developing severe COVID-19, a new study reports. Additionally, more microscopic hemorrhages were found in the brains of APOE4 carriers who contracted coronavirus. Researchers report those with the APOE4 gene also are more susceptible to developing long-term symptoms following COVID infection, including an increased risk of mental fatigue.
While there is an association between obesity during midlife and an increased risk of Alzheimer's disease, researchers say the link doesn't necessarily extend into later life. A new study revealed higher genetic risk for Alzheimer's and lower BMI, especially in older men, was linked to an increased risk of Alzheimer's disease and predicted the disease progression.
Axon myelination is significantly disrupted in patients with Alzheimer's disease. Researchers also found brain cells of men and women vary significantly in how their genes respond to the neurodegenerative disease.
A new study reveals pericyte degeneration may influence the development of Alzheimer's disease.
A new study sheds light onto a fundamental mechanism underlying the development of Alzheimer's disease. Researchers believe the findings could lead to new forms of therapy for those living with the disease.